Chemical PE: The Long Awaited Evidence
I came across an article that captured my attention:
“Chronic papaverine treatment: the effect of repeated injections on the simian erectile response and penile tissue.”
To investigate the effect of chronic papaverine treatment, seven monkeys underwent repeated intracavernous injections for one year. One monkey died* after 56 injections; the others received a total of 100 each. The strength and duration of erection were recorded after each injection, and the erectile tissue was examined histologically at the end of the study. Over the long term, papaverine maintains its erection-inducing capability, but it does cause pathologic changes in the erectile tissue: minimal to marked fibrosis at the injection site and HYPERTROPHY** of smooth muscle in the non-injected area of the corpus.
* The death was not related to the papaverine treatment
**Hypertrophy= Increase in size
I was surprised by this so I decided to email the researchers. I asked them if the monkeys gained any girth or length from the treatment. One of the researchers said off hand that they did not. The second researcher said that they did. I will post my correspondence with this second researcher here.
Please don’t email the authors of the article yourselves. They probably won’t reply. They only replied to me because I claimed to be a urology student. If people start bombarding them with emails I will be to blame.
Here is my correspondence with the second researcher. English is not his first language.
Dear Professor xxx
I am an undergraduate student studying at Edinburgh University in the UK. In the course of my studies I came across an article that you authored in 1987: “Chronic papaverine treatment: the effect of repeated injections on the simian erectile response and penile tissue”. It is stated in the article that the subjects exhibited “hypertrophy of smooth muscle in the non-injected area of the corpus”. I was wondering if you could possibly elaborate on that. Did the entire corpus increase in size or were the effects only visible on a microscopic level?
Dear Mr. xxx
According to your question, I didn’t measure the size of the corporeal body anatomy in the monkeys that were treated with vs. without papaverine hydrochloride. On a microscopic level, however, there was a significant and tremendous smooth muscle increase in the areas where scar formation and inflammation due to the injection was not evident. The smooth muscle hypertrophy was so strong in comparison to the control group that even a non-pathologic educated doctor or even a urologist could realize the difference immediately.
The second thing is that I would not expect that the penile in total or the smooth muscle of the corpus cavernosum does induce an increase in penile length and circumference with chronic use of papaverine hydrochloride, because the relaxation of the smooth muscle of the corpora cavernosa becomes evident when it is relaxing and the penile length and circumference is increasing according to the tremendous arterial inflow with initiation of an erection.
I hope this information will help you.
Dear Professor XXX
Thank you very much for responding to my question. I am extremely grateful that you took the time to reply. Am I correct in thinking that chronic papaverine treatment resulted in a visible increase in the length and circumference of the simian erection? If this was the case, do you believe that this was due to prolonged hypoxia or intense intracavernosal pressure?
Dear Mr. XXX
Prolonged hypoxia did not occur because intracavernous blood gas analysis was performed which was published in another paper in British Journal of Urology. As long as the erection lasts up to six hours, you should have a positive balance concerning the pO2. Therefore, hypoxia is not the reason for the smooth muscle increase after the papaverine treatment. I neither believe that the intracavernous pressure is the reason for the smooth muscle increase, but rather the improved oxygenation over such a long time (one to four hours). Based on this basic knowledge I developed the Kiel concept for patients that underwent a nerve sparing radical prostatectomy. Those patients do receive Viagra 25 mg every night over a period of one year. The overall results which are published several times in various journals demonstrated, that after one and a half year the erectile capability of the patients who received Viagra every night improved more or less to the status prior to surgery in 93 % compared to those who just used Viagra on demand that did report full erection in 68 %. We also performed additional animal studies that were done in the Pfizer lab that demonstrate, that an improved oxygenation within the corporal bodies by giving Viagra enables a full recovery of the erectile response even with a reduced arterial inflow under neurostimulation induced penile erection. It clearly demonstrates, that an increase in the oxygenized smooth musculature is the key point for improvement and recovery of the full erectile function.
I hope this will help you further.
Dear Professor XXX
Thanks again for replying to my questions. It is a great privilege to receive knowledge this way. I have one final question about the study: Did the chronic papaverine treatment visibly increase the erect length and circumference of the entire penile organ?
(from his secretary)
Dear Mr. XXX
Prof. XXX asked me to send you the following reply:
He did not measure it, but he thinks it did.
Hope this will help you – sorry for the late reply.
So there you have it. Definative proof from an expert that the chronic use of ED meds like papaverine or caverject can cause your penis to grow. What works for monkeys will probably work for humans. The monkeys would not have practised a mannual routine during the treatment.
Last edited by london100 : 02-21-2012 at .