What's the deal with pumping in sugar water ?

Most of the discussion was about full package pumping so using something like a long johnny tube which I think is about 4” by 9” and about half a coffee cup of sugar.
I guess for a standard cock only tube about half that amount ?

I haven’t found anything indicating the proportion of sugar to water for this purpose so your estimate is probably a good place to start.

Nobody took this suggestion seriously. I think its an interesting idea. I’m also thinking about coming up with my own “Pumping Sauce.”

This is what I have thought up so far: 1/2 cup pineapple juice, 1/2 cup watermelon juice, 1/4 cup papaya juice, 1/4 cup beet juice, 1 tsp olive oil and a cup or so of warm water mixed with Epsom salt to finish. Thoughts?

It seems like a low risk experiment. Besides the urethral infection risk, that should be minimal since urine will wash out any sugar that wanders into the urethra after pumping, all I can think of is osmotic lysis (which shouldn’t play a role unless it’s somewhere around 80% sugar and the skin integrity is broken I think, probably a higher percentage since sucrose is a pretty big molecule for dermal penetration and I don’t think has any special properties to consider) and AGE reactions (advanced glycation end products), which are unlikely to occur without a significant expression of amylase in the skin, which I don’t think occurs.

Perhaps the penis has some sort of vascular reaction due to the sucrose akin to the way the digestive tract and liver receives increased blood flow after the digestion of a meal?

Maybe there is some unknown potential for various sugars as transdermal microcirculation regulators?
Cardiovascular responses to the ingestion of sugary drinks using a randomised cross-over study design: Does glucose attenuate the blood pressure-elevating effect of fructose?

Is there a ratio of sugar to water?

Are we talking about sucrose or another sugar? Some sugars do influence fluid pressure, like mannitol (if you consider it a sugar).

The first step is verification of the phenomenon.

Has anyone here verified it yet?

Sucrose is a gap junction permeant.

“However, recent X-ray diffraction data show that the channels of crystalline gap junctions (typical of uncoupled cells) are indeed closed, because they are inaccessible to sucrose (a gap junction permeant).”

Gap junction structure and cell-to-cell coupling regulation: is there a calmodulin involvement?

“In endothelial cell culture, simple sugars effectively impair mechanosensor proteins.”

Endothelial mechanotransduction proteins and vascular function are altered by dietary sucrose supplementation in healthy young male subjects - PMC

“Hypertonic sucrose solution applied to an arteriole segment along the apparent conducting pathway attenuated propagation significantly, which is consistent with its reported effect to decouple gap junctions between cells.”

“It is suggested that the opening of KATP channels in vascular endothelium and subsequent hyperpolarization of that cell type mediate coronary microvascular dilation in response to hyperosmolarity.”

Propagation of vasodilation in resistance vessels of the hamster: development and review of a working hypothesis

“In this regard, porcine coronary arterioles (81 +/- 2 microns) were isolated, cannulated, and pressurized for in vitro study. Hyperosmolarity (300-345 mosM) was produced by adding D-glucose or D-sucrose to the extravascular solution. After the arterioles developed a stable vascular tone, a graded vasodilation was observed when glucose or sucrose was incrementally administered.”

Endothelial ATP-sensitive potassium channels mediate coronary microvascular dilation to hyperosmolarity

“Direct intercellular communication via gap junctions is critical in the control and coordination of vascular function. In the cardiovascular system, gap junctions are made up of one or more of four connexin proteins: Cx37, Cx40, Cx43, and Cx45.”

“Direct electrical communication between endothelial cells and vascular smooth muscle cells via gap junctions is thought to play a relevant role in the control of vasomotor tone, providing the signaling pathway known as endothelium-derived hyperpolarizing factor (EDHF).”

This review paper mentioned glucose incubation influence on expression of Cx43, but that’s probably not relevant to this. I really only am including this paper because it describes in detail different aspects of the connexins, their structure, etc..

https://www.lie bertpub.com/doi … 9/ars.2008.2117

“In response to vasoactive factors and to shear stress elicited by blood flow, the endothelium secretes vasodilating or vasocontracting autacoids, which adjust the contractile state of the smooth muscle. In endothelial sensing of shear stress, the osmo- and mechanosensitive Ca2+-permeable TRPV4 channel has been proposed to be candidate mechanosensor.”

https://journal s.plos.org/plos … al.pone.0000827

“It is interesting to note that shear
stress upregulates the expression of Cx43 in cultured endo-
thelial cells (6, 38) and in the endothelium of rat cardiac
valves (93), which is consistent with the idea that Cx43 is in-
volved in the sensitivity to mechanical stimuli.”

https://www.lie bertpub.com/doi … 9/ars.2008.2117

“The sucrose gap technique is used to create a conduction block in nerve or muscle fibers. A high concentration of sucrose is applied to the extracellular space, which prevents the correct opening and closing of sodium and potassium channels, increasing resistance between two groups of cells.”

https://en.wiki … iki/Sucrose_gap

Discussion:

So what is sucrose doing when used in pumping?

I’ve tried it once for about 40 minutes, I didn’t notice an increase in size. I’ll try it again later.

I noticed altered sensation, which I’m not certain was real or just a placebo effect.

In summary, what are the potential known mechanisms?

Nerve signal disruption, vasodilation can be caused via neuron. You can cause priapism by a sympathetic nerve block. There are also drug abuse complications that “deplete nerves” and cause priapism, sometimes resulting in the need for amputation. From what I understand about this, the sympathetic nerves within the penis suppress vasodilation, while the parasympathetic nerves can trigger vasodilation. I guess I should read more into this subject and overcome my disinterest in the nervous system. Please don’t get any ideas, these are the kinds of things I’m hesitant to mention out of fear for people’s safety.

A nice paper on “Physiology of Penile Erection and Pathophysiology of Erectile Dysfunction” talking about nerves.

https://www.ncb i.nlm.nih.gov/p … les/PMC1351051/

I don’t know why sucrose would block sympathetic nerves that constrict arteries, but not parasympathetic and somatic nerves that dilate arteries. Perhaps sucrose dilates via endothelial gap junction effects, so it doesn’t matter what the nerves are doing? Perhaps the distribution of sucrose is different for different regions. I find it hard to believe sucrose could penetrate to the dorsal nerve cord in sufficient quantity to do anything, but could it enter the mucosa of the glans to effect endothelial cells? Most likely, but I don’t know by how much or for how long.

Priapism following a lumbar sympathetic nerve block

Endothelial gap junction disruption, depending on the connexins influenced, or the combination of connexins in a hemichannel, could do different things, vasodilate or constrict. Studies say it causes artery dilation, which is kind of perplexing because if sucrose is disconnecting gap junctions, how does the upstream artery know to dilate? Maybe just through the shear stress of increased blood flow? Maybe they dilate in the absence of transmission?

Sucrose apparently is a permeant that enters gap junctions, maybe they enter alone, maybe they chaperone something else, maybe they leave the junction open so things can leak out. Needs more clarification.

Sucrose could also just have an effect due to osmotic influence on arteries.

It’s an assumption it works on arteries, it might work on veins, or it might work on both. There’s also the mechanosensory aspect of it, maybe it’s an inhibitor of the dreaded contraction response to high forces.

I’m going to keep reading and thinking about this, keeping track of links slows me down quite a bit. I still haven’t verified this phenomenon even occurs, so all this speculation about mechanisms might be for nothing. I’m sure my interest will be peaked again later if I can verify the phenomenon.

This is not proof read, it’s just some notes.

I appreciate you taking the idea of pumping with sugar water seriously. That was a long post and a lot of information.

What do you think about my pump sauce idea, pumping with fruit juice? They are loaded with sugar. I’m not sure if it’s a silly idea or not.

I’d like to verify that sugar has some sort of effect first, then try to characterize what that effect is. The nerve blocking function of sucrose is pretty interesting, I’m skeptical that it’s a quality unique to sugar. Who knows, it might be the underlying mechanism of the GI tract and liver being able to change the distribution of blood in the body during digestion. I don’t think it’s solely an osmotic effect because I’ve already tested that hypothesis with salts (KCl, MgSO4, some others too) and it didn’t seem to do much of anything, granted salts would have different qualities. There did seem to be a slight effect from MgSO4, but pretty much negligible.

Some fruit juices contain protein degrading enzymes which don’t sound like a good idea when skin permeability is already disrupted from pumping. Some people also have allergic reactions to some component of fruit juice that manifests as sores, there’s more than one version of this so likely there are multiple different potential allergens, some people get mouth sores from eating an apple (the glans is a mucous membrane like the inside of the mouth), some people get burn like sores from lemons, if we’re talking about mangoes you can develop a severe allergy to urushiol and the real danger in that is that urushiol can cause cross over immune response and create an autoimmune disease. I suspect the fruit mouth sore reaction has something to do with latent viral infections being activated by something in the fruit, because it’s not uncommon in oral herpes for things to trigger a reactivation.

It’s generally wise when developing a pharmacological method to use purified substances to avoid unknown complications and to quantify the effect of any given substance for reproducing findings. The variability of plant material is high, it can change based on the location grown, time of the year, the strain of plant, the health status of the plant, and immensely complicating things like how many fruits are on the tree. There’s just too many unknowns in fruit. If you come across some useful response from fruit though, it might be worth isolating the active agent(s), which, depending on what it is, can be easy or very hard.

I’ve evaluated at least 100 different chem PE substances about the same way, usually evaluating whatever literature I can find on it before trying it. It’s not a bad hobby, I like reading. It almost doesn’t matter to me that they all seem to be dead ends, I enjoy the process and learn some new things along the way.

I’ll try it. I will start buy mixing up a sugar slurry in hot water and using a mixer. Them a will pour that into my tube. Get a hot bath going. As hot as I can stand it. Get in and soak for a bit. Then I will stand up, put my cock into the tube start pumping and get back into the tub. I will pump for 30 min and see how that works. After i will just release the tube, put cock ring on, rinse off and wash get out. We will see what happens

Both pineapples and papayas contain protein degrading enzymes. I don’t see that as a problem though.
I’m also not concerned about allergic reactions. I can test it on different areas before I try putting it on my phallus.

As far as purification and the “unknowns,” I’m not really concerned. :-)

If I do try this, I was thinking about buying toe shields and using a small cock ring on top of it. This way nothing will actually enter my urethra.

You will be concerned if you get an ulcer from it.

Connective tissue only recovers when it has an organized scaffold to build on.

If you disrupt that order, the best you get is scar tissue, at worst you get a ulcer that has to be excised.

I’ve had an ulcer before, it was from a scab I kept picking at. After a while, it was unable to do more than form a scab and it would bleed at the slightest rubbing. I had to have that portion of my skin cut out. I had it for years before getting it removed.

So I have tried it twice now. I’m not seeing any benefit to post pump size from it.

I probably won’t try it again.

With a surger slurry? It’s going to take more then twice. I will do it twice a day for a week that should show something if there’s something to it

The first time I just put some sugar in the tube with a little water, the second time I used a highly concentrated sugar solution. Both times I used an electric heater wrapped around the tube. I think I’m going to try a weaker solution one more time tonight because I have some sugar left in a glass (lab training compels me never to return a reagent to the primary container) and some left over solution.