Thunder's Place

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STDs

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Originally Posted by marky777
Eventually, it will happen. But less money will be made. My professor at Uni has made most of his money by having his chemical patents baought up and SHELVED. Follow the money, and you won’t be far wrong.

Agreed - less money will be made by the industry, but the first entrant will not care about the industry, only their own profits. The idea of a shelved cure is intriguing - I don’t know enough about the business to say whether a small pharma co that thought they really had the cure for herpes would allow a larger player to buy the patent. I would imagine it would take a tremendous amount of money to match the amount made by going to market with it (essentially 100% market share and nearly instantaneously).

No doubt though that the pharma industry is fucked up beyond belief. Same with healthcare, but that’s another issue.


Start: 6.6bp x 4.875eg, 2006: 7.2bp x 5.00eg (5.5 base), 2009: 7.6bp x 5.25eg (6.0 base)

28876 28885

Esc, that link doesn’t say anything about female-to-male transmission, it just says that some subtypes of the virus might be more easily transmitted through heterosexual intercourse (which typically means male-to-female transmission) compared to others.

I have no doubt that female-to-male transmission is much higher in developing countries than the US or Europe, but I would assume that that’s due to differences in male genital health (e.g., other untreated STDs) without any evidence otherwise.

Not that I’m about to go sleep with a Thai prostitute, since I’d then probably end up with the other STDs, if not HIV :)


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Originally Posted by Para-Goomba
Esc, that link doesn’t say anything about female-to-male transmission, it just says that some subtypes of the virus might be more easily transmitted through heterosexual intercourse (which typically means male-to-female transmission) compared to others.

I have no doubt that female-to-male transmission is much higher in developing countries than the US or Europe, but I would assume that that’s due to differences in male genital health (e.g., other untreated STDs) without any evidence otherwise.

Not that I’m about to go sleep with a Thai prostitute, since I’d then probably end up with the other STDs, if not HIV :)

http://en.wikipedia.org/wiki/HIV

“In high-income countries, the risk of female-to-male transmission is 0.04% per act and male-to-female transmission is 0.08% per act. For various reasons, these rates are 4 to 10 times higher in low-income countries.”

Still low, but worse than in the West. Though I have to say that even .4% as insinuated by the above wouldn’t be that terrible of an odd of contraction.


Start: 6.6bp x 4.875eg, 2006: 7.2bp x 5.00eg (5.5 base), 2009: 7.6bp x 5.25eg (6.0 base)

28876 28885

ESC the process of bringing a drug to market takes between 12-15 years and as much as a billion dollars. The amount of drugs that complete the whole process and make it to market to generate money are few. Even some great ideas cannot be executed, especially with limited resources of a smaller company. It’s a financial gamble that all but a few companies can actually afford.

There are companies that do all of their business by selling their products to big Pharma who will then shelf the drug.

Originally Posted by Esc

Agreed - less money will be made by the industry, but the first entrant will not care about the industry, only their own profits. The idea of a shelved cure is intriguing - I don’t know enough about the business to say whether a small pharma co that thought they really had the cure for herpes would allow a larger player to buy the patent. I would imagine it would take a tremendous amount of money to match the amount made by going to market with it (essentially 100% market share and nearly instantaneously).

It would sell for a lot of money. But it would not make big profits in the first few years. The cost of bringing a drug to market is huge. You have the development, the trials, the lawyers, the advertising… and in the patent negotiations the Big company would make much of this to get the price down.


I'm fed up of having a signature!

Esc,

Wow, the thing that surprises me most there, assuming the wiki page is up-to-date and accurate, is that the chances of male-to-female transmission are only twice as high as female-to-male transmission for vaginal intercourse; I always thought it was a much higher ratio. The female-to-male risk apparently isn’t completely trivial even in developed countries. More reason to be careful, I guess!

Strange that the wiki page doesn’t mention the risks of anal sex or male-to-male transmission :confused:


Please :donatecar to Thunder's Place to keep it running.

How many diseases have been declared incurable and then cures have been found - At one time most STDs were incurable. As well as many tropical diseases and those caused by poverty.

Just for the record I do not catch colds, flu , viral coughs. I cured myself of those 22 years ago. I never have anti-flu Vaccinations

The cure for colds was simplicity itself. I used to have really bad colds flu etc., until I was going to start a new job, and felt a sore throat coming on which meant ten days of misery as I used to be very badly affected by flu etc.

I looked around the house (It was late evening ) and all I had was a bottle of Green Chartreuse.(I did look closely at the Bleach bottle but decided against that!)

So I gargled with the Chartreuse - i thought I was going to die as some ran down into my lungs. and I was continually coughing for about half an hour.

Eventually I fell asleep in the chair. When I woke up I noticed my throat felt a little easier, but just thought it was the numbing effect of the alcohol.

I went to bed and next morning when I woke up the sore throat had gone. and I have not had any colds/flue since.

Marky777

If I went to a clininc and asked to be tested They would bprobaly show me the door and tell me to stop wasting their time.

8inch.

I don’t get cold sores now - none in eight years.

Certainly I must have some antigens in my system Possibly what I did was to give them extra Ooomp! which enables them to kill the virus before it can replicate. (that’s it’s only intention)

Originally the povidon Iodine was hailed as a virus killer from tests carried out In Vitro. But they had to withdraw that claim, as it didn’t work In Vivo I simply found a way of making it effective In Vivo. because the lime juice exposes the virus to the Povidon iodine by dissolving the lipid protection

I imagine that because the virus is killed it can’t replicate so eventually dies out in the system.


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Last edited by petitfaun : 11-22-2009 at .

The best method of preventing flu and colds etc. is in my opinion, supplementation of vitamin D. I can’t remember the last time I was ill, and prior to starting supplementation I would get colds regularly during the winter.


Decemeber 2007: 5.8" BPEL x 4.9" MSEG

Current:-------->7.7" BPEL x 5.7" MSEG (7.2" NBPEL)

Current Goal:--->7.6" BPEL X 5.8" MSEG Do or do not, there is no "try".

I never take vaccinations that aren’t required. I read a study once stating that children who washed their hands three times a day or more had a significantly high rate of common illness such as the flu or cold.

This may seem counter intuitive at first - but ultimately their washing of the hands does not give their immune systems the opportunity to be exposed to common germs and build up defenses.

What doesn’t kill you only makes you stronger!

PetitFaun - That’s some interesting info on your treatment for the herpes for sure.

This thread took some interesting spins.

The original question asked concerned blow jobs and the likelihood of contracting an STD.
The bottom line on that one is: How lucky do you feel? Because YES it does happen and it only take ONCE.

Everyone wants to know the answer to that one question:
How much can I get away with?
Well, how lucky do you feel?

Sure there’s all sorts of factors concerning who what where when and why, that could minimize your risk.
Given those, how lucky do you feel?

Carry on.


I was gonna say, RootCap's hot. - kitten

Originally Posted by RootCap

Everyone wants to know the answer to that one question:

How much can I get away with?

Well, how lucky do you feel?

Thanks RC

This is one of the few things that stops us form swinging. I thought I was just being OCD :D


I'm fed up of having a signature!

Originally Posted by 8inchM
The inmune system can not attack the virus on the latent period of the virus (as you can read on the link above), so the herpes cure is related with finding the way to make the virus visible to our inmune system.

bigger-8inchM!

Since you bring it up, this guy just got a grant for doing the research from this article. So, something may show up down the road.

http://www.sciencedaily.com/release…61013201826.htm

Quote

Research Holds Promise For Herpes Vaccine

ScienceDaily (Oct. 16, 2006) — A study by a Montana State University researcher suggests a new avenue for developing a vaccine against genital herpes and other diseases caused by herpes simplex viruses.

In a study published earlier this year in the Virology Journal, MSU virologist William Halford showed that mice vaccinated with a live, genetically-modified herpes simplex virus type 1 (HSV-1) showed no signs of disease 30 days after being exposed to a particularly lethal “wild-type” strain of the virus.

In contrast, a second group of mice that received a more conventional vaccine died within six days of being exposed to the same “wild-type” strain.

“We have a clear roadmap for producing an effective live vaccine against genital herpes,” said Halford, who works in MSU’s Department of Veterinary Molecular Biology. “Although my studies were performed with HSV-1, the implications for HSV-2-induced genital herpes are clear. Overall the two viruses are about 99 percent genetically identical.”

An estimated 55 million Americans carry herpes simplex virus type 2 (HSV-2), which causes genital herpes. Infection is life-long. Approximately 5 percent of those with genital herpes - 2 million to 3 million Americans - suffer outbreaks one to four times annually. A vaccine offering life-long protection does not exist.

The key to Halford’s research was understanding how the herpes simplex virus overcame the body’s natural defenses.

A cell infected with the herpes simplex virus sends a warning to neighboring cells. This warning — an interferon response — causes neighboring cells to enter “an anti-viral state” akin to putting on a suit of armor, Halford said.

However, herpes produces a protein, ICP0, that tricks every infected cell into destroying its own armor. Once the cell’s armor is gone, the virus can propagate itself and spread to other cells, which are in turn tricked into lowering their defenses.

In his research, Halford created a vaccine where the genetic instructions that make ICP0 were disrupted. Without instructions on how to do its clever ICP0 trick, the virus can still establish an infection in animals, but the spread of the virus is stopped long before disease can occur.

“In short, we can disarm the virus such that it is absolutely unable to cause disease, but is still remarkably potent as a vaccine,” Halford said.

In a human vaccine, the genetic instructions for ICP0 would actually be removed, creating an “attenuated,” or weakened virus. The rest of the herpes simplex virus’ genetic code would remain intact. Measles, mumps, rubella, polio and yellow fever vaccines are all made from attenuated viruses.

Research in recent decades has focused on subunit vaccines, which are made from one piece of a virus (a protein subunit). Subunit vaccines are safer than attenuated virus vaccines because the subunit cannot replicate or cause disease. However, subunit vaccines have proven ineffective in protecting people against persistent infections like genital herpes and AIDS, Halford said.

“From a theoretical standpoint, subunit vaccines are poor mimics of a natural virus infection,” Halford said. “There’s not enough there for our immune systems to build a protective response against the actual virus.”

Halford, 38, is aware that his approach is controversial.

“This is where I’m young enough that I don’t know how long it can take to swing popular opinion among scientists and clinicians,” he said. “I would hope that in five to six years the scientific community would be willing to seriously consider these proposals.”

Halford hopes to find a commercial partner or secure government funding to advance his research toward a human vaccine.

“I’d like to take this concept from the chalkboard to the clinics,” he said.

follow-ip

And 3 years later, the grant for a vaccine. And it is just a vaccine, not a cure.

http://www.sj-r.com/health/x1128406…-herpes-vaccine

Quote

Posted Oct 09, 2009 @ 11:48 PM

A scientist at Springfield’s Southern Illinois University School of Medicine has received a $400,000 federal grant to develop a vaccine for genital herpes.

William Halford, associate professor of medical microbiology, immunology and cell biology, is principal investigator for the project, which recently received a two-year grant from the National Institute of Allergy and Infectious Disease.

Genital herpes, a lifelong infection that has no known cure, infects about 1 billion people worldwide.

The goal of Halford’s study is to develop a vaccine that can be given to children so they have no risk of acquiring the disease later in life.

I have no medical training so what I say may be complete nonsense. (that’s a good start) :)

But what I have learnt is that the virus (as apparently most virus’s have) is a lipd ( or fatty covering)
This is a very good protection for the virus, indeed for everything that needs protecting Lipid covering is used extensively in the animal kingdome for protection within the body.

So I imagine it is not possible t remove the lipid covering by general means as it would remove the protective coating of other vital tissue etc which require protection.

Therefore it seems to me that the only way to reach the virus is through the skin, and so needs something that will penetrate the skin in sufficient coverage to engulf the area where the virus is located, and dissolve the lipid (fatty) covering of the virus. Then the second stage is to cover the area with the virus killer which again penetrates the skin to kill the virus.

Whether the two can be applied simultaneously has yet to be determined. I can’t try that as I don’t get any more viruses And I would not suggest anyone try it just in case the virus was not harmed and then produced it’s own antidote to the application of the two chemicals.

With regard to the “acid” used - lime juice. . I imagine this is citric acid but I think there must be other chmicals used.

This is because the people who produce Betadine Povidon Iodine, also sell this with citric acid. But there seems to be no records of that mixture curing the herpes virus.


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