Giving chemical PE a try

DMSO had the same effect for me. Full disclosure, My DMSO was mixed with PABA, testosterone|stanozolol and tadalafil; but the rubbery, stretchy, relaxed feel when flaccid was definitely from the DMSO as none of the others should have this effect

BTW, you should also consider topical spironolactone for your scalp. It’s a DHT blocker so it should block DHT in your scalp while letting most of your systemic DHT operate as usual. Together with minoxidil and possibly red light therapy you’ll be hitting it with all of the big guns.

Thanks for sharing your journey, I’ll be following along :)

Thanks for the recommendation. I looked into that several years ago and never followed up but now might be the time for the topical spironolactone.

I’m on vacation with my wife’s whole family this week so efforts are minimal. I’m doing manual stretches for 5-10 minutes a day tops and no pumping (I left the equipment at home as I can’t imagine having to explain to the in-laws if one were to find the equipment!).

I am continuing to inject IGF-1 LR3 every other day while here. No apparent effects yet, but I’m just one week into injecting the IGF.

Interesting theory and discussion. Hope it works out well!

I’ve already broken my simplicity rule. When I saw that the newest ADS stretcher devices were so cheap on eBay I ordered the LeLuv Deluxe that should be in the box when I get home from vacation. I plan to use it a few hours a day when it’s not too much of an interference. When I’m working remotely that might be 4-6 hours. Otherwise it might be an hour or so. We’ll see how it goes integrating it into my life and I’ll update accordingly with a framework and status reports.

First use of Trimix this evening. Because of my schedule I had to put it near the end of my day when I still had enough time to ensure detumescence in a safe window.

I injected Trimix measured to 1mcg of PGE-1. My erection began in the first 30 seconds and was at 100% after about 15 minutes. My CC was straining for 2.5 hours at 100% and then came down to about 90% at that point. It’s been 3.5 hours and I’ve dropped to about 75%.

Wow, fellas. I can really, really feel the tunica fatigue and mild discomfort. It started about an hour into the medication effect.

I completed my 30 minutes of post-heat manual stretching and 10 minutes of heated 5inHg pumping prior (the pumping was earlier today and the last 10 minutes of manual stretching was just before injecting).

I applied topical DMSO 50% immediately after injecting and again after about 90 minutes. Not sure if it will have an effect but it’s easy enough to throw into the mix.

Thanks to Newyorktexan I decided to add some low pressure heated pumping to the Trimix state and did two sessions totaling 25 minutes. After that things were pretty uncomfortable so I just let it ride.

I have to admit I was a little nervous about the potential for a long night on a small starting dose, but based on this experience I think 1mcg is a good dose for me. A little less might also work, so I might try 0.75mcg just to compare. At 1mcg I have 100 doses on hand. The pharmacist recommended that I freeze the vial between uses which gives it a long shelf life, so I imagine it will last me nearly long enough to use it up.

I’ll call it a night in a bit and the plan for tomorrow is IGF-1 LR3 and the non-injection exercise regimen. It will be interesting to see how I feel after a night’s sleep.

I can see how helpful it will be to use an extender once the erection has subsided, as the level of fatigue is tremendous and I imagine there is a great benefit to riding the wave of this prolonged CC expansion into hours of low level tension. Once I’m up to speed I’ll add that in.

Thanks to Kyrpa’s thread on US heat, I’ve also got a therapeutic US machine that should be here soon which I’ll incorporate into the routine.

Update to first Trimix session:

After I logged off my update last night I stayed at ~75% through the 7th hour with the decremental change so slow that I finally decided to reverse it so I go safely go to sleep. So I injected 500mcg phenylephrine and the erection detumescence was within 30 seconds.

7+ hours of 75-100% CC rigidity is a little long to feel 100% secure, especially at this point in my experiment where I have no experience. This was with just 1mcg PGE-1 in my Trimix dose! Pretty shocking response but I suppose that is somewhat good news to be sensitive rather than the opposite.

So I’m going to back down to 0.5mcg PGE-1 dose and see how it compares. 90+% in the 2-4 hour range feels manageable for the moment, but it’s also nice to know that the phenylephrine antidote works so well and is just as simple as injecting the Trimix. It also feels good that I’m so responsive. If 0.5mcg PGE-1 is my effective dose then my single vial is good for 200 doses, assuming it doesn’t degrade in the freezer over the time it takes to use it up.

If the lower dose results in similar intensity but shorter duration, which would be ideal, then I might consider using it 5-7 days a week, both to increase the volume of work and to use up as much as possible before refilling my Rx. Also, as I get more experienced and comfortable I might shoot for the longer duration of up to 6 hours, but that is down the line.

Anyway, a reiterating word to anyone who is considering chemical PE with PGE-1: Start WAY lower than you think, slowly work your dose up and have both oral pseudoephedrine and injectable phenylephrine on hand. Priapism is no joke but is easily reversed if you’re prepared.

Are you sure you’re measuring the PGE1 correctly? 1mcg should have no effect. 10-20mcg is the usual dose. Did you brew it from powder or buy it? Your .5mcg equaling 200 doses really caught my eye. 1mg of PGE would yield 2000 doses at .5mcg per dose.

Hey, da_dt, thanks for looking out.

I got it from a compounding pharmacy with a prescription.

I did recheck my calculations multiple times before injecting. I also got the recommended starting dose and volume from the pharmacist as a confirmation.

I think I have the math correct, but please do check me on it:

I have a 10mL vial of Trimix. It has 10mcg/mL of alprostadil (PGE-1). I injected 0.1mL of the Trimix. This was 10 units on my 100 unit/mL insulin syringe.

10mcg/mL / 0.1mL=1mcg

This led to a 7+ hour erection at 75% or above (almost 3 hours at 100%), which was fatiguing, as I mentioned above. Definitely an effect!

Perhaps the addition of the other Trimix components make it more effective per unit PGE-1 than PGE-1 alone.

Your math checks and the other ingredients in Trimix enable erections for sure, I just never realized how much so. They only put 100mcg of PGE1 in that whole vial! Glad you had the antidote.

Tonight I decided to inject Trimix again, this time using 0.5mcg worth of PGE-1. Based on my tiny dose I think I’ll use it every day that my schedule allows.

The dose was pretty much on the money. 95-100% erection for 2.75 hours and then 75-90% for another 0.75 hours for a total of 3.5 hours. Got the fatigue in the tunica after about the first hour. After nearly five hours I’m still pretty tumescent, but at thick flaccid hang rather than erect. Totally safe in terms of priapism complications.

Did the usual heat and 10 minutes of manual stretching prior to injection. DMSO after injecting and again after about 90 minutes.

Once I was up I heated pumped in 10 minute sets for a total of 30 minutes.

One thing I thought to do tonight is using a hot tub during the Trimix session in the hopes that it helps make the tunica more pliable. I won’t be able to do it every session because I’m planning on having my many of the sessions during my remote work hours, but I will use the hot tub when I can. (I have a great job, but unfortunately I can’t do it from a hot tub.) Tonight I got into a 106 degree hot tub for 20 minutes with about a 95-100% erection. I have no idea how warm my intra-urethral temperature might be to correlate with some other heat experiments, but being totally submerged in the hot tub at that temp is just generally pretty challenging after 12 or 15 minutes. It feels a lot like a 190 degree sauna. So hopefully it adds a little something.

Earlier this afternoon (post weight training) I injected 10mcg of IGF-1 LR3. I try to time the IGF injections after regular workouts so I get the benefit of any systemic circulation, in case there are any.

Third session of Trimix. Did the usual manual stretches of 30 minutes total and managed to spend 1.75 hours in my extender earlier today.

Decided to experiment with a tad more than last night, this time injecting 0.6mcg. It was interesting. Had 90-100% errection for about 2.5 hours. I spent 30 minutes in a heated pump at 5inHg.

Then went to the hot tub for 20 minutes where it remained 90-100%. But once I was out I came down to about 70% and I thought for certain that I was on the way down. Since I thought my session was over I masturbated to ejaculation, thinking it would put and end to things, but boy, howdy was I wrong.

I went back up to 100% for the next 4 hours!

I think the hot tub and post-hot tub state, which is physiologically like hard cardio and its recovery, resulted in some detumescence, but once I was relaxed again and stimulated the Trimix kicked back in harder than before.

I just reversed it at 7 hours with 300 mcg phenylephrine and am now down to a very tumescent but non-erect state.

After today’s session my tunica is sore along its entire length. As I think I’ve mentioned, I’ve never achieved this level of fatigue doing anything. Then again, I’ve never had a 7 hour uninterrupted session of any other kind of exercise before.

I’m still learning, but it seems less is definitely more. Next time I think I’ll use 0.4mcg.

Although I have no realistic scenario to experiment as you are here, its super interesting. The extended erection / hypoxic (maybe) is really interesting strategy and based on some things Ive read will be a factor to make you larger.

Keep.safe, thx for the info!

Can ypu describe where / how you are injecting these drugs. Im squeemish with needles, needles in my dick…man.

Glad you are keeping us informed.

Hey, XL,

I’m basing my chemical PE course on a program shared by a member called stagestop from many years ago. The basic idea is that the several hour-long intense erection in the corpora caverns (CC) from PGE-1-containing compounds (in my case Trimix) acts like internal clamping or ballooning, while it also may act to loosen collagen cross-linking at the tunica. Along with this, taking some supplements (both oral and topical) that might also create some collagen loosening (in my case PABA and topical DMSO) and doing a minimal amount of some kind of traction on the tunica every day (short duration manual stretches, some pumping and extender when possible) could result in permanent enlargement.

The Trimix (or whatever PGE-1 compound) is injected directly into the CC to create the erection. It is a long-used ED medication. So while injecting into the penis has some mental challenges, if good, clean technique is used and you know what you are doing, it’s not a big deal.

I’m also injecting IGF-1 LR3 into the CC every other day. The idea behind this is that after some stress on the internal erectile tissue of the CC the IGF-1 will bind the CC smooth muscle and prompt smooth muscle enlargement. The thought here being that this will result in bulkier erectile tissue inside the CC and create even more expansion during erection, which will lead to even more growth. Stagestop said that he felt the IGF-1 was primarily good for girth, but it seems to me that 3-dimensional expansion will result, assuming this works at all.

This is still really experimental. I’m not sure how many people have tried and stuck to this program on this board. But there have been reports of success, both in published results from experiments, and anecdotally on this board (and supposedly on others, thought I’m not on them).

I myself seem to have topped out in the results I can get compared to how much effort I’m willing to put in for other modalities. I think I reached my limit on ligamentous lengthening and now am focused on tunica enlargement. I think this is slower, but has much more potential for continuous gains over time, and the chemical approach, while challenging, is essentially passive relative to the duration of the ‘workout.’ I don’t have to sit in a chair with weights hanging between my legs for hours a day, for example.

So for me, this is an approach that makes sense. After years of using different modalities to varying degrees of success but essentially incremental results either because of my physical limitations or limitations in making an ongoing intense effort, this is likely my last attempt at a sustained effort to enlarge significantly. If it works for me, I’ll let everyone know. I’d love to get the results that stagestop did, but even a percentage would be worth it to me.

If you, or anyone else reading this, is interested in this approach, then please do read stagestop’s thorough reporting of his MD-guided experience. It’s super long, but the clarity, warnings about potential dangers, endless answering of questions and clear reporting of benefits, risks and limitations are all there. It is worth reading the whole thing (well, nearly the whole thing. The last couple of pages kind of devolve after he stops responding some years after the first post).

Also, you really, really have to know what you are doing. Honestly, one should have the guidance and support of an MD for the PGE-1 compound use. There are some big risks if you don’t know what you are doing and you can really injure yourself permanently. There are cases of men who have to go to surgery to repair their penis from priapism that went on too long, and this most likely leads to permanent deformity and dysfunction. Infection is another risk. Some guys have tried to mix their own injectables from cheap online sources of the PGE-1 powder and had big problems. There are other risks, like scarring and Peyronie’s disease that can result. The list goes on. Like any medical procedures, there are risks and benefits, and the risks here are extremely small if you know what you are doing, but not so much if you are winging it.

Please consider this a warning label for my thread. I might point back to it to any future reader so there is a clear-eyed understanding that this isn’t just something you try without a LOT of background work and deep thinking, especially if you are new to injections, needles, penile physiology and anatomy, etc.

My plan is to update on my process regularly, both as a document for my own journey, and, hopefully another clear description of this process (I really admire and appreciate stagestop’s thread and hope to contribute one along the same lines in terms of future value).

My approach is one-minded but the reported results have been mixed. So I’m ok with it not working, but if it does, I’ll let everyone know how it goes and then people can make up their own mind as to if it is worth the effort or not for them.