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Erectile Dysfunction and ALT-711

Erectile Dysfunction and ALT-711

Some of you guys may remember me mentioning ALT-711 when looking at AGE’s (Advanced Glycation Endproducts) which is a condition that occurs in aging (particulartly in diabetes) where crosslinking occur between a sugar and a protein. Effects are thickening and stiffening of arteries, valves, veins etc. This is one of the main reasons people with diabetes suffer ED, but it happens in non diabetics too (though usually in later life). It seems Alteon has recognised this and began trials in January:

(Evaluation of AlagebriuM in Erectile Dysfunction in Diabetic Males on PDE5 Inhibitors)

In January 2005, we initiated a Phase 2 trial of alagebrium in erectile dysfunction (ED). EMERALD will assess the ability of alagebrium to restore erectile function in diabetic patients with moderate to severe ED who achieve limited benefit from current treatment with PDE5 inhibitors, the first class of orally-active compounds approved for the treatment of ED. In a pre-clinical rat model of diabetes, alagebrium has demonstrated an ability to restore erectile function —through what appears to be a unique mechanism of action – and thus may offer significant potential as an adjunctive treatment for diabetic erectile dysfunction.

EMERALD is a randomized, double-blind, placebo-controlled Phase 2 pilot study being conducted under the direction of Wayne J.G. Hellstrom, M.D., Professor of Urology at Tulane University School of Medicine and an author of many of the seminal studies in ED. Approximately 40 male diabetic patients age 18 to 70 will be enrolled and randomized to receive oral doses of either alagebrium (200 mg once daily) or placebo tablets for a 16-week period in conjunction with their PDE5 inhibitor therapy. The primary endpoint of the trial will be based on the International Index of Erectile Function (IIEF) questionnaire. Secondary endpoints of efficacy will be self-reported improvement in erections (according to a Global Assessment Question) and measurements of change from baseline in penile blood flow.


If you’re feeling adventurous then I’m pretty certain that this stuff could be formulated to order.

Author of many “seminal studies.” Nice phrasing. :)

What diabetics need to keep in mind, re: ED, is the adage, Use It Or Lose It. Neuropathy and nerve damage, vascular damage, can be ameliorated through an active and committed theraputic program. Instead, many suffer ED for long periods of time without taking steps to get blood flowing again, and regularly. Nocturnal erections cease. Sexual ones are less efficient or not efficient at all, yet the diabetic waits, either out of anxiety of discussing this or in the hope that somehow, magically, function will return on its own.

It doesn’t.

There are (at least) 6 very efficient vasodilator drugs which are easily available through docs. They are well-tested; odds are very high that at least one of them will work very well.

Nerve damage cannot be repaired in the absense of oxygenated blood. Tissue atrophy, ditto. Simplistic to say, but more erections make more erections more likely.

(And, while I am on a soapbox, pumping can be super therapy for diabetics.)

Note that the alteon link mentions PDE5 drugs twice. They will figure strongly in the results of the alagebrium dosage, is my bet.

Thanks for the post, Shiver.



I think jelqing and masturbating are more enjoyable and economical ways to increase blood flow to the penis, but that’s me.

(12/5/2008) BPEL: 7.75" EG: 5.75" BSFL: 8.1" FL: 5" FG 4.25"||New Goal: NBPEL: 8" EG: 6"

Technique: 95% Wet Jelqing, 5% Low Vacuum Pumping

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