Pramipexole

Has anybody tried pramipexole to increase libido, EQ and ejaculation frequency? I have been taking pramipexole for about a month, starting from 0.125 mg per day to now 1.0 mg per day. However, the pro-sexual effects are still not very evident. I wonder what dosage I need to take in order to experience the pro-sexual effects?

It’s an anti Parkinsons drug. Even the medics don’t know exactly how it works.

Danger danger.

It is a dopamine agonist and that is how it works.

Indeed, it’s a selective D2 / D3 dopamine agonist, the those receptor subtypes play a role in libido. At 1 mg a day you should be seeing those effects, but they don’t manifest in everyone. If you can tolerate the potential side effects ramp it up a bit further.

Do you think its reduced your refractory period? Are you spacing out the doses? E.g. 2 - 3 times a day?

And what are your expectations from it?

It worked for me modestly well at below your dosage, but the side effects were a bit annoying. You might wish to stack it with other things to assess your libido profile.

If you could, please refrain from using this drug.

The libido increase is not worth the potential side effects.

Since I posted the last message, I have been increasing the dosage steadily until I reached 3 mg per day (1.5 mg, 2X a day) on Saturday. I think I will stay at this dosage for a while.

I have not had sex for a few weeks (I do not watch porn or masturbate) so I really don’t know if my refractory period has decreased. Last time I had sex, I was still on 1 mg, and what I found was that the orgasm was more intense with stronger contractions. Now at 3 mg I have random erections throughout the day, especially at around 2 hours after dosing. I also have very strong nocturnal and morning erections. I feel horny all the time but not to the extent that some people claim to experience while on pramipexole.

My expectation is to have a higher libido and to be able to have multiple orgasms. From what I read in different forums, some people claim that they feel so horny that they need to ejaculate 6 to 7 times a day. I want to experience that level of libido and multiple orgasms when I have sex.

I really don’t know what to do now. Should I increase the dosage to the max (1.5 mg 3X a day) or should I switch to, say, ropinirole, another dopamine agonist to see if it works better on libido? I tolerate pramipexole very well. I have almost no side effects even at 3 mg per day, except for some tiredness. I sleep extremely well on pramipexole and feel very refreshed every morning when I get up. I can switch to ropinirole but I am a bit worried about what kinds of side effects there will be.

Do pramipexole and ropinirole act on the same receptors? Which one is better for libido according to your experience? I don’t want to try cabergoline because apparently it will damage the heart valves.

Well it sounds like you’re getting reasonable effects from 3mg. It’s a shame the half life for the drug isn’t longer as with cabergoline.

So long as you’re monitoring and managing your side effects and general health, I don’t see a problem taking the dose a bit higher. At some point you’ll saturate your D2/D3 receptors enough.

I’ve got no hands on experience with ropinirole, but its got a similar half life and acts on the same receptor subtypes, so I don’t think you’d see much benefit from changing to that.

I’m not sure its productive to be quite as horny as you want to be though ;) When I’ve had dopamine releasers at a suitable dose I just end up with a chaffed dick.

Maybe try stacking your pramipexole with L-dopa, or other libidogenic compounds?
A bit of Viagra in combination with the prolactin reduction should certainly obliterate the refractory period.

Although I have not yet had sex while on 3 mg, just like you said I think I am getting good effects. This morning I had a rock hard erection that wouldn’t quit, and without any extra stimulation I found myself leaking precum. I think I will stay on 3 mg for now until I have the chance to “try it out”. I am also a bit worried about the withdrawal effects if I need to reduce the dosage. Are you still on pramipexole? If not, did you experience any withdrawal effects when you weaned it off? How high did you go on premipexole?

I am thinking of adding mucuna pruriens, which is essentially L-dopa and see if it can augment the effects of pramipexole. I actually read a post in another forum which talked about taking premipexole and ropinirole together. However, I don’t think my doctor will allow that. 4.5 mg a day is the max for restless leg syndrome but I don’t know what exactly the max max is as far as using it for libido is concerned.

I have tried many other libidogenic compounds and I only find mucuna pruriens and maca to be somewhat effective. Viagra and cialis only help with erections so they are not exactly what I am looking for. Cabergoline damages heart valves so I don’t want to take that. My doctor prescribed me with wellbutrin (another dopamine agonist) many years ago but I could not tolerate the anxiety. The same goes for yohimbine. I was prescribed mirtazapine, which also acts on dopamine receptors. Mirtazapine made me really horny, but the problem was that I could not tolerate the extreme sleepiness it caused (12+ hours of sleep). In addition, I could not control my ejaculation at all. I also tried trazodone, which also worked a bit but was very sedative.

What other medications/supplements would you suggest?

This drug is unbelievable. I finally had sex this morning for the first time after increasing the dosage to 3 mg. I felt like my penis was hypersensitive and was as rock hard as I had taken viagra. Every rub would send shock waves over me but I could still control my orgasm. Finally when I came, the contractions were so strong that my pelvic muscles were in spasm. I completely lost count of how many times I shot because I felt like my whole body was shut down and ripped apart. The orgasm was so powerful that I could not even scream or moan. The whole thing must have lasted several minutes. Then I completely passed out and actually fell sleep, which I almost never do after having sex. My partner said that I came a lot but I did not see it because everything was cleaned up when I woke up - half an hour later.

I did not have multiple orgasms but honestly I don’t want to because I am not sure if I can survive them. My penis was still half hard though half an hour after I had come, and I could feel that I could go again if I wanted to. However, I just called it a day. With orgasms like this, once is really enough.

I am wondering if I still need to increase the dosage to the max?

This sounds like I should try it. Let me look into it.
I’ll give you a brief history of my ED.
I am about to turn 47 in a couple months. In 2011-12 I went on anti depressants for 2-3 months. First Zoloft, then Prozac and wellbutrin. That almost immediately caused me to lose erections after penetration with zoloft, prozac almost kill the ability to get an erection and wellburtin made me clueless about how close I was.
I have struggled with it ever since. I never had an issue before these. My biggest issue before that was that I wasn’t long enough to do my wife in the ass cos I couldn’t just fuck her in the ass with my shaft, so the head was getting a lot of friction, and blowing sometimes - and to make it worse, I’d have to penetrate her 2-3 times cos she or I would inadvertently move and it came out, and 2-3 penetrations = blow. This seemed to not phase her though, she was still very hot, very sweet and still very happy to do anal (however little I’d anal her, I’ve had to dildo her ass then penetrate it and blow). Fast forward that 3 yrs - where things for worse and worse.

Anyway now a days, I am barely getting hard enough to penetrate her vaginally, I come too soon cos I am semi soft and smaller and end up heading her, and at the end of it, no one is very satisfied.

Anyway I’ve had very little PE experience but my current situation almost puts erectile quality as paramount, getting a good erection and keeping it up till I decide its been good - and I’ll settle for doing her in front, till she says OK time to do my ass, and even penetrate it and blow is fine.
You guys think this pramipezole is a worthwhile try ?

Uh, whoa. Do you HAVE to take it 3x a day to get these results? It makes me tired so I just do my dosing at night.