IGF DES (Not IGF Lr3)/DMSO/PGE1/POTABA included into PE Routine
DES (1-3) IGF-1 (NOT THE SAME AS IGF-1)
Most athletes have heard of IGF-1 (Insulin like growth factor-1) and the amazing anabolic effects it has been reported to have upon protein based tissue such as muscle. Des (1-3) IGF-1 is over 10 times (1000%) more anabolic than IGF-1. Now that is amazing!!
IGF-1 is actually produced from both Insulin and growth hormone in the liver and other tissues. IGF-1 is made up of 70 amino acids in a chain. Well, when a clever chemist removes the last 3 amino acids in the IGF-1 chain (the N-terminal tri-peptide) it becomes Des (1-3) IGF-1 and 1000% plus more anabolic. Why? IGF-1 circulates through our blood stream and tissue 24 hours a day, 7 days a week. Unfortunately, most of the IGF-1 is inactive because it is bound by another protein called (get this) IGF-1 Binding Protein-3, or IGF-1-BP-3 for short. Since bound hormones can not fit into and trigger a receptor-site, the majority of circulating and muscle IGF-1 can not trigger an anabolic stimulus. Like tons of cellulite in a porno movie (who watches those?) there is little good stuff happening. However, when IGF-1 is altered and becomes Des (1-3) IGF-1 the binding protein IGF-1-BP-3 can not bind to it and it is totally active. Another reason Des (1-3) IGF-1 is so potent is its unique ability to fit into lactic acid altered IGF-1 receptor sites. (YUP) When we train we burn carbohydrates as a fuel to make cellular ATP. When cells switch to this ATP pathway, the by-product is Lactic Acid. This is of course the cause of most of the burn we feel during intense or higher rep sets. Well, the lactic acid build-up is called acidosis, and it destroys the shape of some receptor-sites for period of time. Therefore some anabolic/anti-catabolic hormones have difficulty merging with their respective receptor- site and triggering a response (such as even unbound IGF-1). Not so with Des (1-3) IGF- 1, the super growth factor. It fits into the IGF-1 receptor-site even after acidosis. Des (1- 3) IGF-1 is unbound, over 10 times more potent than IGF-1, and it picks receptor-site locks. Too bad it has only a few minute active-life.
Did you know that our body’s make Des (1-3) IGF-1 naturally? Most un-informed individuals claim other wise, but it is true. When an athlete trains lactic acid builds up in muscle tissue. As we know, there is always IGF-1 / GH present in the blood stream and tissues (including muscle) from prior work-outs and other metabolic factors. That lactic acid burn triggers IGF-1/GH secretion from both prior and present work-outs. Unfortunately, lactic acid destroys some of the IGF-1 present in muscles being trained. But wait, this is good too!
Lactic acid also cuts (truncates) the last 3 amino acids off the 70 amino acid chain of “some” of the surviving IGF-1 and creates Des (I-3) IGF-1. So acidosis increases GH/IGF-1 production in the liver, “unbinds” IGF-1 locally in the muscle being trained (burned), destroys some of the IGF-1, and converts some IGF-1 into Des (I-3) IGF-1. Huh, good deal. And the synthetic form of this super anabolic stuff is beginning to show up on the black market more frequently.
Now with that information on Hand, DES seems to be the superior IGF version…
Of course IGF would never just work alone, but incorporating this into a PE regimen, i feel could help speed the process up.
Now, if one really wants to get into Chem PE…PGE1 could be administered to achieve an 110% erection for 3-4 hours. This Priapism is its own workout, pushing the penis to the limit from the inside out. Administering some IGF DES after the penis has come down from the erection would be an optimal time as the most receptors would be available for binding with the IGF after such an intense “workout”.
Throwing in some DMSO + Pabo, during Jelquing (as lube) can help unlink collagen, thus helping the PE process.
PGE-1 / para are said to both have “collagen” un-linking properties. If true, this would definitely help during the PE process.
Anyone have any success or more info on IGF DES and PEing?
I know IGF DES Worked for me when shot into my “lagging” muscle groups, so from my first hand expieriece, IGF does work…just how well does it work when combined with a REAL PE program.
But with a solid Regimine like the one above, Chem PE can only help (if any)