I trolled through the cialis site to view the entire patient booklet and found a couple of interesting things:
“Single doses up to 500 mg have been given to healthy subjects, and multiple daily doses up to 100 mg have been given to patients. Adverse events were similar to those seen at lower doses. In cases of overdose, standard supportive measures should be adopted as required. Hemodialysis contributes negligibly to tadalafil elimination.”
In other words, if you get a 3 hour boner, take sudafed and head to the ER if you get to 4 hrs hard and get ready for a real painful needle to the dick.
So there would seem to be little possibility of an overdose with 20mg or even 40mg (doubtfully really 40mg if from offshore). It would seem that at some point, both efficacy and side effects plateau with higher and higher doses.
From the same source, based on how cialis is cleared from the body, after 5 days of daily use, the level of cialis in the bloodstream stabilized at 1.6 times the daily dose.
So although cialis ‘daily’ is prescribed at 2.5 and 5mg, even at a true 20mg level, with daily use, the maximum level in the body would be 32mg, well below the high levels tested above.
There are charts in the patient handout that show that with increasing dose, the main things that change are the occurrence of side effects. So that should be a good guide.
At all dosages, the main warnings are:
No more than once a day. (Seems kind of silly, 5mg once a day vs 20mg once a day).
No nitrites (like nitroglycerine), watch alcohol and blood pressure meds - issue is onset of low blood pressure. So if you get dizzy, check your BP.
I know you should also watch grapefruit - it tends to keep a lot of kinds of medicines in your system longer, including cialis.
I had missed the large mg testing in my earlier reading, but the above facts are what led to my testing protocol based on side effects. I have done offshore 40mg per day and onshore research chem ‘superman’ pills claiming, I think 25mg of both cialis and viagra and wasn’t impressed. (Madison James research).
The addition of viagra impacted sensitivity negatively for me vs cialis alone. I doubt the dosages were accurate vs. True prescriptions.
YMMV, but with offshore cialis 40mg so cheap, I think thrre’s a lot of headroom to experiment with. You can always use a pill splitter twice to cut a “40mg” down to 4 “10mg” doses to keep it safe.
As with everything else in PE, the slower the better seems to be common wisdom. Change one thing at a time and record the results.
- Jeff
