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Patent 5159



A method for causing a permanent increase in the length and girth of a male subject’s penis, the method comprising treatment comprising the step of (a) administering to the male an effective amount of a vasodilator selected from the group consisting of a vasodilator per se and compositions thereof comprising a pharmaceutically-acceptable diluent or carrier, to induce a cumulative prolonged engorgement of the subject’s penis; and (b) repeating step (a) as necessary to cause the increase during the treatment. A potentiator which enhances the effect of the vasodilator may also be used.”

A currently approved US patent for a PE method that utilizes the erection inducing and collagen regulating functions of the hormone PGE1. This hormone and other chemicals are commonly mixed and administered by injection to treat erectile dysfunction. Here, a variation in the concentration of these component chemicals leads to an erection of longer duration which is claimed to result in significant and permanent penile enlargement.

Patent Pending Chemical PE


Same topic.

The Holy Grail of PE is found!!!


Progress report of individuals who are receiving the treatment from the patent originator:

Chemical PE progress report

Chemical PE report #2

Last edited by penismith : 11-09-2006 at .

Penismith, you rule. It’s an ambitious project, but perhaps we can consolidate some of the valuable info here into a comprehensive overview of what’s known about PE science someday. The first step is to get all the disparate info in one place, as you’re doing here.

(Please do feel free to delete this comment later as the thread moves forward.)


“The article in the first post is important because, although we already knew that low flow priapism can result in permanent and substantial penis enlargement, we did not know that the same is true for high flow priapism. This casts doubts on the theory that priapism causes PE via the build up of hormonal metabolites in the penis (a low flow theory). This is also important because this adolescent appears to have gained as a result of prolonged partial rather than prolonged full erections. We already knew that prolonged full erections could result in a significant increase in penile length and girth over time.”

This thread discusses high flow priapism as a possible cause of penis enlargement.

penismith - Does high flow priapism increase penile size?

Originally Posted by Para-Goomba
Penismith, you rule. It’s an ambitious project, but perhaps we can consolidate some of the valuable info here into a comprehensive overview of what’s known about PE science someday. The first step is to get all the disparate info in one place, as you’re doing here.

(Please do feel free to delete this comment later as the thread moves forward.)


Yea, there will be a lot of rearrangements and consolidation taking place. Then, one day, I hope that we can weave it into an easily read and logically organised review of sorts.


“”Megalophallus as a sequela of priapism in sickle cell anemia: use of blood oxygen level-dependent magnetic resonance imaging.

Kassim AA, Umans H, Nagel RL, Fabry ME.

Department of Medicine (Division of Hematology), Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 10461, USA.

Priapism is a common complication of sickle cell anemia. We report a little known sequela of priapism: painless megalophallus, with significant penile enlargement. The patient had had an intense episode of priapism 9 years previously and his penis remained enlarged. Blood oxygen level-dependent magnetic resonance imaging revealed enlarged, hypoxic corpora cavernosa. Megalophallus probably resulted from permanent loss of elasticity of the tunica albuginea due to severe engorgement during the episode of priapism. This sequela needs to be recognized by physicians because no intervention is necessary and sexual function seems to remain intact.”

This thread covers published research articles discussing permanent and substantial penis enlargement as a result of low flow priapism. The thread author also proposes the use of the hormone PGE1 to enlarge the penis. This is the same key ingredient that is used patent 5159 (see above).

Megalophallus through PE


“Arch Androl. 2006 Jan-Feb;52(1):1-8.

Histologic study of the tunica albuginea of the penis and mode of cavernosus muscles’ insertion in it.

Shafik A, El-Sharkawy A, Khamis A, Zaghloul S, Abdel Gawad M, Elwy D.

Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt.

The tunica albuginea (TA) is the outer covering of the corpora cavernosa (CCs) and corpus spongiosum (CS) of the penile shaft. The different histoanatomical patterns of the TA, as well as the mode of attachment of the ischio-/bulbo-cavernosus muscles (ICM, BCM) to the TA, were studied, aiming at elucidating their role in the mechanism of erection. Twenty-eight cadaveric specimens (18 adults, 10 neonatal deaths) were studied morphologically and histologically after staining with hematoxylin and eosin and Verhoeff-van Gieson stains. The TA consisted in 20 specimens of 2 layers: inner circular and outer longitudinal, in 6 specimens of 3 layers: inner circular, longitudinal and outer circular, and in 2 of only one longitudinal layer. The CS TA was formed of one layer of longitudinal fibers. The mode of cavernosus muscles insertion into the TA revealed 3 patterns. The conjoint BCM and ICM formed a fibrous belt over the CCs in 18 specimens, a muscular belt in 6 and no belt in 4. The functional role of the variations in the TA morphological structure is not exactly known. We hypothesize that the 3-layered TA gives more penile rigidity than the double and single layers. Considering the type of cavernosus muscles insertion into the TA, it appears that the fibrous belt exerts more CC compression than the other 2 types of insertion.”

This thread discusses a study aimed at determining the role of the tunica albuginea in the erectile process. This structure is a thick collagen containing sheath that surrounds the corpora cavernosa, or the main two erectile chambers. They find a variation in the number of sheaths in different individuals. The authors also discuss skeletal muscles that regulate erection. The thread participants hypothesise that the number of tunica layers an individual has will probably affect their ability to gain with PE.

Tunica Differences


“…understand the difference between men and women concerning the PC (pubococcygeus) muscle and the BC (bulbocavernosus) muscle.

There are three illustrations. They are attached to this and the next two posts. The fourth post down contains the explanation of why women contract their PC muscles to strengthen their vaginal and urinary systems and men contract their BC muscles for better ejaculation and stronger erections (and to test their LOT).

Please open all three illustrations before reading the text or view this thread with the illustrations presented in the text (en español aqui).”

This thread covers the difference between the pubococcygeus muscle and the bulbocavernosus muscle and includes several detailed cartoons of the male reproductive organs. The development of BC muscle tone can increase the rigidity of erections.

Locating the bc muscle

Yea, I am thinking that we can beef the wiki up in such a way that science minded newbies can more quickly get up to speed and join the more technical discussions.

Poor information accessibility is so often the limiting factor in scientific progress. The quality of our newbies keeps going up and when they develop and really sink their teeth into some of the key questions, big things will happen.


“Here’s a very simple possible answer to the question, why do gains slow with training.

Collagen fibers tend to align along the lines of applied stress. The more the stress, the more complete the alignment. The more the fibers align, the harder it is to stretch the tissues. Collagen has a higher tensile strength than steel.

Maybe that’s all there is to it. Deconditioning would then consist of allowing the orientation of the fibers to become more random, not necessarily to have fewer fibers.”

The tunica albuginea (TA) is the outer covering of the corpora cavernosa (CCs) and corpus spongiosum (CS) of the penile shaft. This structure is composed of structural proteins including collagen which is arranged in rope or cable like fibers.

ModestoMan - Why gains slow!


“I just found this interesting article on connective tissue.”

This post contains four links to articles on connective tissue. Collagen is a major component of connective tissue.

ModestoMan - Why gains slow!



Your Most Plentiful Protein
About one quarter of all of the protein in your body is collagen. Collagen is a major structural protein, forming molecular cables that strengthen the tendons and vast, resilient sheets that support the skin and internal organs. Bones and teeth are made by adding mineral crystals to collagen. Collagen provides structure to our bodies, protecting and supporting the softer tissues and connecting them with the skeleton. But, in spite of its critical function in the body, collagen is a relatively simple protein.”

This post contains an easily understood description of collagen.



“As we know, fascia can be stretched. The “tunica” that we so often mention consists of fascia (“Buck’s fascia”).

Apparently, even the world outside the PE community knows fascia can be stretched. Here’s another interesting analogy to bodybuilding. Stretching your fascia gives your muscles room to grow, just like stretching your tunica gives your penis room to grow.

Check out the article:…ves/issue10.htm”

This thread discusses methods used by body builders to stretch structures that are like the tunica.

Stretching Fascia—Another BB analogy


“This article says that “struts” help contain the diameter of the CCs during an erection. Therefore, the strength of these “struts” may be a limiting factor in increasing girth.
The tunica albuginea of the penis(above) consists of two fibro-elastic connective tissue layers, an inner circular and an outer longitudinal. The inner circular connective tissue layer serves to contain the erectile tissue’s diameter during erection. This is analogous to inserting a balloon into a drinking straw and attempting to blow it up. In the corpus cavernosum, this layer is also continuous with “intracavernosal struts” or spokes radiating from the connective tissue surrounding the cavernosal or deep artery. These act to increase the ability of the circular layer to contain the diameter of the expanding penis.”

This thread discusses an often ignored structural component of the penis, the intracavernosal struts. They are contained in the cavernosum which are the two major erectile champers. The referenced publication in the first post also describes the two major lavers of the tunica which are a circular inner layer and the outer layer which is composed of parralel collagen fibers which run the length of the cavernosum.

CC “Struts” may limit girth growth


“In leg lengthening surgery, the tibia and fibula or each leg are broken and the two halves of each bone are affixed to a threaded splint that holds them apart. The threads are advanced to separate the bone segments 1mm per day until the desired new length is achieved.

Have you ever wondered whether PE gains work essentially the same way? Bigger talked about “pulling out” his penis by hanging, but the amount he pulled out exceeded anything that was within his body. Perhaps the tunica has a weak point, analogous to the break in the bone above, which stretches in response to regular stress, while the rest of the tunica remains substantially unaffected.”

This thread references a technique that is employed in leg lengthening. The leg bones are cleanly broken laterally and then a device is attached to the leg which keeps the bone separated by small amount. As the space between the broken bone is filled in, the device is adjusted to maintain the gap. Interestingly, the soft tissue surrounding the bone will grow to accommodate the new longer leg length. This proves that soft tissue including muscle and nerves can elongate in response to a chronically applied force.

Penis lengthening like bone lengthening?

Last edited by penismith : 11-04-2006 at .



…in the article they find that the penis is enlarged and BMP4 staining corresponds to the enlargement. That is, they detect a higher than normal level of BMP4 in the enlarged penis…BMP4 is almost certainly a positive regulator of penis growth…They record the high BMP4 staining in the GLANS of the penis…I also noticed that these penises seemed longer but not thicker than average. I wonder if the penis gets longer first and then fills out? It is also interesting because the glans has less AR down regulation than most of the rest of the penis.”

This post references a publication in which a protein called BMP4 was attached to small beads which were placed in rat penises. This treatment resulted in a significant increase in the size of said penises. BMP4 is a component of a complex signal transduction pathway that regulates tissue differentiation and development. Of interest, the penises appeared, in the provided images, to exceed average measurement more in length than in girth.

penismith - Why gains slow!


“Increase first in length then width of penis; growth of testes and scrotum.

Source: Data from Tanner JM. Growth at adolescence. Oxford: Blackwell Scientific Publications, 1962.”

“Testicular enlargement and change in scrotal coloring are the first signs of puberty among males,
usually occurring between 10.5 and 14.5 years of age (11.6 on average) during SMR stage 2
(Figure 2). The development of pubic hair is also observed during SMR stage 2. Testicular
enlargement starts between 9.5 and 13.5 years of age in most males (SMR 2 to 3), concluding
between the ages of 12.7 and 17 (SMR stage 5). Spermarche, or the onset of sperm production,
occurs at approximately age 14 among males. The onset of puberty among males is highly variable,
thus nutritional needs of male adolescents of the same chronological age are also highly variable.”
Attached Files
File Type: pdf Puberty.pdf (187.2 KB, 0 views)”

This post links a study that references a publication that states that the penis lengthens before filling out during puberty.

penismith - Why gains slow!


“(Studies previously referenced in this thread) state that trauma is believed to be the initiating factor in Peyronies’s. This trauma is thought to result in bleeding into the subtunical spaces. Fibrin deposition is one of the initial consequences of microvascular injury. Fibrin deposition is known to form in Peyronie’s plaques not in normal or scarred tunica. “Plaques consist of dense collagenous connective tissue with reduced and fragmented elastic fibers.” Calcification is present but only in 30% of patients.

TGF-beta expression is detected in 86% of Peyronie’s cases.

“Intra-tunical injection of TGF-Beta1 or its analog, cytomedulin, produced histological alterations such as chronic cellular infiltration, focal and diffuse elastosis, thickening, disorganization and clumping of the collagen bundles.”

It is all here in this study, I really wish I could post the whole thing. I just changed the wording a little. There is so much more in there as well, but I can’t spend all night paraphrasing it.

Now re-read this abstract:

The objective of this study was to evaluate the possible role of transforming growth factor beta 1 (TGF-beta(1)) antibodies (ab) for the prevention of fibrotic effects of priapism in a rat model. In total, 30 adult Sprague-Dawley rats were divided into five groups. Priapism with 6 h (group 1), priapism with 6 h+ab (group 2), priapism with 24 h (group 3), priapism with 24 h+ab (group 4) and control (group 5). Priapism was induced with a vacuum erection device and a rubber band was placed at the base of the erect penis. At 1 h after the initiation of priapism, TGF-beta1 antibodies were given intracavernosaly. All rats underwent electrical stimulation of the cavernous nerve after 8 weeks. Intracavernous and systemic blood pressures were measured during the procedure. Rats in group 1 showed significantly higher (intracavernosal pressure (ICP) pressures to cavernous nerve stimulation and had higher ICP/BP ratios when compared to other groups. Similarly, histopathologic examination revealed less fibrosis in group 2, compared with the other groups. Consequently, TGF-beta1 antibodies antagonise the fibrotic effects of TGF-beta1, especially in cases with duration of priapism less than 6 h.International Journal of Impotence Research advance online publication, 29 July 2004; doi:10.1038/sj.ijir.3901261

PMID: 15284835 [PubMed - as supplied by publisher]…t_uids=15284835

We are dealing with TGF-beta1 and fibrosis with both Priapism and Peyronie’s. The link is there, it is microvascular injury and the resulting fibrosis and collagen buid up via TGF-beta1. Again, notice how they induced Priapism.

“Priapism was induced with a vacuum erection device and a rubber band was placed at the base of the erect penis. At 1 h after the initiation of priapism, TGF-beta1 antibodies were given intracavernosaly.”

This results in TGF-beta1 production in this study! We are doing simular things to our penis and are likely getting simular results, TGF-beta1 production. We know what TGF-beta1 does, it results in fibrosis and extensive collegen build up. In the treatment of Peyronie’s with Vit E or Acetyl-L-Carnitine results in the reducion of the build up of these “Plaques (which) consist of dense collagenous connective tissue with reduced and fragmented elastic fibers.”


I am not currently as certain of the stated conclusions and now believe that ModestoMan’s concerns (below) are yet to be adequately addressed.


“One thought that comes to mind, which may or may not have been touched on already, is that the scientific publications listed describe fibrosis of the CC tissue itself. This is different from fibrosis of the ligaments, tunica, or Buck’s fascia.

Our limiting factors in PE are these latter structures, however. I’m not sure we care (from a purely size perspective) what happens inside the sinusoids and smooth muscle of the CC’s. It seems that’s more of an erectile issue than a PE issue.”

This post is a rebuttal to the hypothesis presented above. This hypotheses is discussed for several pages and many references are provided.

ModestoMan - Why gains slow!


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