I think there is a very important point here that is being overlooked, is that we are enlarging more than one type of tissue (connective tissue, and smooth muscle.) remek and I have a theory, or hypothesis if you will, that given the two major tissue types involved here are substantially different from each other in composition and structure, the stimulus and process of enlargement is very different. Smooth muscle fibers retain mitotic capacity and can therefore increase their numbers (hyperplasia) and they are also capable of increasing in size (hypertrophy.) While, connective tissue fibers have the ability to hypertrophy, they do not (at least to my knowledge) have the ability to regenerate their numbers. Connective tissue must be enlarged by plastic deformation. The approach to achieving a growth stimulus for both requires a two-fold approach.
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