With the exception of a couple very minor injuries I got when I didn’t know much about PE safety, I can’ t think of a single negative consequence of having done PE.
Well, I take that back. During the period of time I worked worked the hardest at it I probably gave up some social time. No regets there.
I can’t answer your question accurately the way you pose it but I can tell you that I came to PE _with_ ED. The exercises have, I think, turned my entire penile vascular system around in positive ways. Because of the type of ED I have, I’ll probably always need one of the drug crutches but my response time to them is very fast now and on lower dosages.
Size increase, btw, doesn’t impede your ability to get it up. Even with lots more cock volume than I had before PE, it still goes up very nicely.