I’ve used both methods on a few different occasions. Most recently ~2 months ago. I think both methods worked a bit for me but nothing too spectacular. My first time I used it, years ago, I had my best response and I did use a loading method. When it first came out there was a lot of hoopla and a lot of money to be made promoting it. I think that hype has settled down.
I actually did a speculative piece in one small journal on the possibility of using it as supplementation for certain muscle-wasting disease states but looking back, I think some of the studies I relied on may have been a bit fudged since a lot of the creatine research was funded by the companies who were promoting it and getting big name exercise scientists to find positive results. One researcher told me so in an e-mail many years ago, when I was doing the write-up. He may have been bullshitting me. Not sure, but I wouldn’t be too surprised. There does appear to be a short-term effect. Whether that leads to long-term real muscle size gains, I’m not sure, even though I have come across studies suggesting it.
Starting Size: April, 28, 2010: NBPEL-7" Girth-6" (base, MSG, glans)