PE, Acne, Testosterone, Androgen receptors

It’s been said many times that administering testosterone or other androgens after puberty doesn’t do much things towards PE because of closed androgen receptors in penis(that’s the general consensus here).

I would like to make an analogy of these androgen receptors. It seems, the fact that a person with acne has more androgen receptors is well studied and true. You can look at this :

Androgen receptor in hirsutism and acne - PubMed "Androgen receptor in hirsutism and acne."

What I’m getting at is the thought that maybe if someone has more androgen receptors in the skin,this being related to acne, can the androgen receptors on the penis still be somewhat active and responsive to testosterone, regarding growth ?

I would like people to post their observations regarding this, some eg would be : you do get acne and you seem to gain well ? or you have acne and you don’t gain well ? or you have acne,very good EQ and and don’t gain ? or some other derivations of these earlier q’s ?

I know it can be that there’s no correlation between these, but maybe there are.

Thank you.

Posting to come back later.

Seems interesting, I have acne and I’ve gained pretty nicely I think.

I personally don’t think there is any significant link.

During the time of my best gains, a few years back, I did have a little acne, nothing severe though.

This study seems to suggest that the downregulation of penile androgen receptors is in fact not responsible for the cessation of penile development.

The effect of testosterone on androgen receptors and human penile growth.
The effect of testosterone on androgen receptors and human penile growth - PubMed

They put fetal human penises into rat bodies ? That’s something…interesting. :)

Are you saying that if you have acne at 30 yo, than maybe your penis is still growing?

Haha I know right?! Lol the write-up is pretty confusing regarding that:D .

No. :)

But, it was concluded that the ones who have acne have more(as a number or as a degree of responsive) androgen receptors. And I think I’ve read many times here that a reason why a penis will not be responsive to testosterone(which has a direct influence on penis growth) is that the androgen receptors on the penis are down regulated on ones past their puberty.

The study which man-of-10 posted is an interesting one, but it’s a little weird if you read it, meaning they literally put human fetal penises into rat bodies to study the effects(or so I understand from the study, if I’m wrong please correct me).

Another study had show that “exposure to exogenous testosterone accelerates the loss of androgen receptors and compromises eventual penile length.” This group of researchers felt that added testosterone was not the cause of reduced penile length nor did it down regulate the number of androgen receptors. The apparent target population was males who, for whatever reason, received androgens before puberty and had smaller penises as adults. (Their conclusion states: “Furthermore, these data support the hypothesis that early administration of androgen to prepubertal male individuals does not result in a shorter phallus in adulthood.”)

They did implant human fetal penises into rats and mice. The penises used in the study were from human fetuses. They found that the administration of extra androgens or a normal amount of them did not change the growth rates, but absence of androgens did affect growth rate. Androgen receptor counts were the same in all subjects.

The results are not valid for someone past puberty. They have no validity for PE.

I don’t think so.. Maybe 0.001 cm/year

I have had pretty bad acne most of my life. Is what you’re saying only applying to older adults? I’m only 18 but I’ve been struggling with severe acne since 12. It’s a lot better now, but what I’m gathering is that people who do have acne most likely have more androgen receptors in the penis than someone without acne. Correct? Therefore the testosterone is more likely to make my penis larger. Does that only apply for externally added testosterone? I can see myself just being very redundant in this post but I’m extremely oblivious to the obvious.

:spam: