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Can You Guys believe this Drug?!?

Is everyone all right? Any symptoms?

Originally Posted by Ngkkh
Is everyone all right? Any symptoms?

For the first time in my life I had high blood pressure but I doubt but don’t know for sure if it had anything to do with it.


I haven't failed, I've found 10,000 ways that don't work. Thomas Edison (1847-1931)

This just sounds downright horrible.

Damn it!!! Condisering the gravity of their statements it seems stupid to continue to use this medication simply to raise libido :( That sucks! While I never thought it was a miracle drug, it does have a slight, but noticeable effect that to me was quite welcome. One wonders whether the low doses used for our purposes, as opposed to those used to treat Parkinson’s disease, still have an effect on the heart valve.

Regardless, I don’t think it’s wise to continue :(


Your training is nothing. The will is everything. If you make yourself more than just a man, if you devote yourself to an ideal, you become something else entirely. Are you ready to begin?

Well, on the upside, I was able to find this quote “The investigators point out that the mean daily dose was higher for cabergoline (3.8 mg) than for pergolide (1.4 mg) or pramipexole (1.7 mg).”

Which is promising in that most of us are only taking 0.5mg every few days. I.e., while we might take 1mg per week, they were taking 26.6mg on average, and therefore others were taking more, and there is no indication that I could find of what dosages were associated with the damage.


Your training is nothing. The will is everything. If you make yourself more than just a man, if you devote yourself to an ideal, you become something else entirely. Are you ready to begin?

Quote

The results showed that 23.4 percent of patients taking pergolide and 28.6 percent of patients taking cabergoline suffered heart damage, compared with just 5.6 percent in the control group.

“These are huge risks,” said Roth.


FUCK - THAT - SHIT.


Horny Bastard

Originally Posted by zaneblue

One cup of coffee shoots 80% of the effect for me; my spontaneous orgasms vanish.

What’s a spontaneous orgasm? Like, when you’re walking down the street?

Originally Posted by Sexual MacGyver
Well, on the upside, I was able to find this quote “The investigators point out that the mean daily dose was higher for cabergoline (3.8 mg) than for pergolide (1.4 mg) or pramipexole (1.7 mg).”

Which is promising in that most of us are only taking 0.5mg every few days. I.e., while we might take 1mg per week, they were taking 26.6mg on average, and therefore others were taking more, and there is no indication that I could find of what dosages were associated with the damage.

Yeah, the damage appeared to be dose-dependent. So, at .5mg risk appears to virtually non-existent.

Has anyone experience of using pramipexole or ropinorole instead of cabergoline?

Parkinson’s Drug Pulled From Market

Mar 29, 4:52 PM (ET)

By RANDOLPH E. SCHMID

WASHINGTON (AP) - A drug used by several thousand patients with Parkinson’s disease is being pulled from the market because of reports of heart valve damage.

The Food and Drug Administration said Thursday that pergolide, sold under the name Permax and also in generic versions, is being withdrawn at the agency’s request.

There are other drugs in the same class that can be substituted, Dr. Robert Temple of the FDA’s office of drug evaluation said at a briefing.

At least 14 patients have needed to have heart valves replaced, Temple said, adding he believes that is an underestimate.


He estimated that between 12,000 and 25,000 people currently used the drug, which is known as a dopamine agonist.

“Our conclusion is that pergolide has no demonstrated advantage over other therapies,” Temple said. “We believe almost all patients can be converted to another drug.”

Pergolide came on the market in 1988. Temple said label warnings were added in 2002 after some reports of heart valve problems were received.

In 2006, a boxed warning regarding the risk of serious heart valve damage was added to the labeling for pergolide.

Temple said withdrawal was requested after two recent studies, published in The New England Journal of Medicine, indicated high rates of valve leakage - up to 20 percent - in patients taking the drug.

He said patients should not stop using the drug abruptly, however, urging them to consult their doctor and either switch to another drug or to gradually reduce the amount of pergolide used.

Other dopamine agonists used for Parkinson’s disease are not associated with heart valve problems, FDA said.

Pergolide is marketed by Valeant under the trade name Permax and sold and manufactured as the generic drug pergolide by Par and Teva.

Temple said a few people may not be able to change to another drug and the agency is making arrangements to have pergolide available for them.

The new studies also found an increase chance of heart valve damage from another dopamine agonist, cabergoline, sold under the name Dostinex, the FDA said.

Dostinex is not approved in the U.S. for the treatment of Parkinson’s disease, but is used at lower doses for other disorders, Temple said. At the lower doses there appears to be little chance of heart problems, the agency said.

—-
http://apnews.excite.com/article/20…/D8O62EDG0.html

On the Net:

Food and Drug Administration: http://www.fda.gov


I haven't failed, I've found 10,000 ways that don't work. Thomas Edison (1847-1931)

Originally Posted by Dino9X7
Dostinex is not approved in the U.S. For the treatment of Parkinson’s disease, but is used at lower doses for other disorders, Temple said. At the lower doses there appears to be little chance of heart problems, the agency said.

Good news, eh?

Originally Posted by trainr
Good news, eh?

I hope that’s the case if it is than it is good news for all us lab monkeys who took it


I haven't failed, I've found 10,000 ways that don't work. Thomas Edison (1847-1931)

Any updates? I heard cabergoline made ppl develop pimples. Is that true?

Originally Posted by Ngkkh
Any updates? I heard cabergoline made ppl develop pimples. Is that true?

I stopped right after I heard about the heart problems


I haven't failed, I've found 10,000 ways that don't work. Thomas Edison (1847-1931)

I’m ordering some


Started: Bpel 7 mseg 4.5

Current: Bpel 7.5 mseg 4.75

Goal: at least 8.5X6.5

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