Below is a study that illustrates some major points. Priapism causes fibrosis. Our Uli type exercises mimic priapism. The types of exercises we are doing a causing a buildup of fibrin. Fibrin deposition follows microvascular injury, the types of injuries we give ourselves while we squeeze our penis to the point where we see red dots, or perhaps even before that. As in Peyronies, which is caused by trauma of excessive bending of your erect penis, we are causing microtears with our exercises. These tears stimulate an immune response in which TGF-beta is recruited. At this point, lots of changes take place including the formation of dense collagenous connective tissues with fragmented elastic fibers. These fibers are quite strong and unless you employ the most herculean of forces after they have developed, YOU WILL CONTINUE TO GAIN NOTHING!!!!!! Forget about newbie gains until this crap is cleared from your penis. In the next post I will tell you how to do so.
Take a look at how they induced Priapism. They used a vacuum to inflate the penis and then the clamped it off with a rubber band. Is this sounding familiar yet? Guys, we need to hit the literature.
Int J Impot Res. 2004 Jul 29 [Epub ahead of print] Related Articles, Links
TGF-beta(1) neutralizing antibodies decrease the fibrotic effects of ischemic priapism.
Sanli O, Armagan A, Kandirali E, Ozerman B, Ahmedov I, Solakoglu S, Nurten A, Tunc M, Uysal V, Kadioglu A.
1Istanbul Faculty of Medicine, University of Istanbul, Istanbul, Turkey.
The objective of this study was to evaluate the possible role of transforming growth factor beta 1 (TGF-beta(1)) antibodies (ab) for the prevention of fibrotic effects of priapism in a rat model. In total, 30 adult Sprague-Dawley rats were divided into five groups. Priapism with 6 h (group 1), priapism with 6 h+ab (group 2), priapism with 24 h (group 3), priapism with 24 h+ab (group 4) and control (group 5). Priapism was induced with a vacuum erection device and a rubber band was placed at the base of the erect penis. At 1 h after the initiation of priapism, TGF-beta1 antibodies were given intracavernosaly. All rats underwent electrical stimulation of the cavernous nerve after 8 weeks. Intracavernous and systemic blood pressures were measured during the procedure. Rats in group 1 showed significantly higher (intracavernosal pressure (ICP) pressures to cavernous nerve stimulation and had higher ICP/BP ratios when compared to other groups. Similarly, histopathologic examination revealed less fibrosis in group 2, compared with the other groups. Consequently, TGF-beta1 antibodies antagonise the fibrotic effects of TGF-beta1, especially in cases with duration of priapism less than 6 h.International Journal of Impotence Research advance online publication, 29 July 2004; doi:10.1038/sj.ijir.3901261
PMID: 15284835 [PubMed - as supplied by publisher]
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