The danger of NO2 supplementation
I recently read a thread that someone posted (sorry poster dude, can’t find the thread) in which the attached document regarding the supplementation of L-arginine (NO2) contained a warning to make sure that the manufacturers “product does not cause an increase in, or stimulate the production of free radicals and/or peroxynitrite”.
So, I did some googlin and came up with some interesting negative peroxynitrite info, a by-product/metabolite of nitric oxide.
“Peroxynitrite is a strong oxidant and nitrating species, the formation of which may be beneficial in inflammatory reactions in terms of an oxidative destruction of intruding microorganisms. Higher concentrations and an uncontrolled generation of peroxynitrite, however, may result in unwanted oxidation and consecutive destruction of host cellular constituents. Peroxynitrite may oxidize and covalently modify all major types of biomolecules, including DNA [6, 7], proteins [8-10] and lipids  as well as various low-molecular-weight biomolecules.”
“Peroxynitrite-induced modification of proteins has been connected with the development of several diseases (for review, see ).”
 Google search for indicated reference found:
“Peroxynitrite (ONOO) is a reactive oxidant formed from superoxide (oO2-) and nitric oxide (oNO), that can oxidize several cellular components, including essential protein, non-protein thiols, DNA, low-density lipoproteins (LDL), and membrane phospholipids. ONOO has contributed to the pathogenesis of diseases such as stroke, heart disease, Alzheimer’s disease, and atherosclerosis.”
A different google search found this:
“The self-decomposition of peroxynitrite has no biological importance because this reaction is too slow compared to other reactions of peroxynitrite, for example, the reaction of peroxynitrite with CO2. The reaction of peroxynitrite with CO2 is specially important in biological systems due to the high concentration of CO2 and the relatively large rate constant for this reaction.”
After further searches and reading for protection against peroxynitrite, most of the info out there suggests that antioxidants protect the body from peroxynitrite. I think I recall reading that antioxidants attack peroxynitrite and NOT nitric oxide. So my theory is, supplementing our NO intake with the appropriate antioxidants will protect our bodies from oxidative chaos produced from NO’s by-product, peroxynitrite. Antioxidants mentioned we’re Glutathione (via alpha lipoic acid and N-acetylcysteine), flavanoids (hesperidin), polyphenols, ascorbate, whey protein, SAMe, selenomethonine,
Comments and ideas on this matter would be greatly appreciated.
Here are some links I found on certain antioxidants, supplements and foods:
Food Sources That Boost Glutathione Naturally
How to Boost Glutathione Levels
Good antioxidant formula here