Somewhere in the article it mentioned 30 minutes, I will have to reread.. It doesnt mention how long the collagen is effected for though. Using DMSO in conjunction with an ADS, if we could get the collagen to soften for an extended period, (perhaps with POTABA supplementation as well), could give us the mechanism to induce length gains in the tunica without ever having to resort to PGE-1 with it’s inherent risks. Duplicating the effect of IGF-RL1 is a different thing - DMSO with DHT may be the way to go there.. More research I think.
I just noticed that I referred to Potaba as aminobenzoate sodium. Clearly a boo-boo. It’s aminobenzoate potassium.
Originally Posted by brazillionaire
From what I’ve read PABA can be put into a DMSO transdermal. Because POTABA is a very similar molecule, I’d expect it to be an acceptable size as well. POTABA and DMSO in conjunction would certainly be very effective for our purposes. Short of human relaxin it may be the best we can do.
Many oral treatments have been studied, but results so far have been mixed. Some consider the use of non-surgical approaches to be “controversial”. … Newer agents targeting the basic mechanisms of inflammation have not yet been studied in larger clinical trials. Such medications include potassium para-aminobenzoate (Potaba), acetyl L-carnitine, propionyl L-carnitine, L-arginine, sildenafil (acting through phosphodiesterase-5 inhibition) and pentoxifylline (acting through TGFβ1 inhibition).
Here’s some info about potaba from drugs.com. This is probably the most parsimonious explanation.
Generic Name: Aminobenzoate Potassium Tablets (ah-mee-noe-BEN-zoe-ate poe-TASS-ee-um) Brand Name: Potaba Potaba is used for:
Treating certain skin conditions and muscle/skin conditions (dermatomyositis). It may also be used for certain problems with the penis (Peyronie disease) or other conditions as determined by your doctor.
Potaba is an antifibrotic in the vitamin B family. It works by increasing the oxygen supply in tissues, which helps prevent the formation of fibrous tissue. Do NOT use Potaba if:
* you are allergic to any ingredient in Potaba * you are taking a sulfonamide medicine (eg, sulfamethoxazole)
So according to drugs.com, here’s the effect of Potaba: “It works by increasing the oxygen supply in tissues, which helps prevent the formation of fibrous tissue.”
I think I see how oxygenating penal tissue could help with PE, however, preventing formation of fibrous tissue sounds counterproductive. This all may depend on the definition of fibrous tissue and whether it’s related to collagen. I’m not in the medical field, so I’m left pretty clueless on that.