papaverine cream--"miracle grow" for PE?
Could papaverine cream help in PE?
The below article has been cited several times in threads on this forum, but I haven’t found much pointed discussion about it.
(The article is copyrighted in a scientific journal, so I can’t post the article here, nor can I provide a link to it. But I’ll post the abstract and citation below.)
Here’s the gist of the article:
- A team of scientists separated pigs into 3 separate groups. Each pig, in each group, was implanted with a tissue expander (similar to those used by women who have undergone a mastectomy, for instance).
- Group A received papaverine locally at the site of tissue expansion via topical papaverine cream. Group B received papaverine via injection at the site of tissue expansion. Group C was the control group. (It received no special medicine.)
- The results, in order of greatest rate of tissue expansion: A, B, C.
- The scientists concluded that topical papaverine cream could be used to accelerate the rate of tissue stretching.
I am using an extender that relies on dynamic splinting to cause the penis to elongate and widen slightly (Penimaster). I also am using the Static Stretcher, a sort of ADS. These devices work very similarly to that of “traditional” plastic surgery tissue expanders.
I suppose my question is obvious: would putting papaverine cream on my stretched unit work the same way as it worked for the pigs?
I’m willing to be the guinea pig on this “experiment,” but I have no way to get 2% papaverine cream (the same used in the scientific experiment). Further, I have two other concerns:
1. What if the papaverine cream causes some unwanted side effect when it comes into contact with sensitive penis skin?
2. I am uncut. Would it be possible that the papaverine cream, if applied topically, would simply cause the foreskin to stretch and elongate (instead of the tunica, etc.)? I’d hate to end up with a 9 inch unit and 12 inch foreskin!
Does anyone have any knowledge or ideas to share? Any experience with papaverine cream (not injections or oral medication)?
P.S. Here’s the abstract and citation, in case anyone on a college campus wants to investigate:
“Accelerating tissue expansion by application of topical papaverine cream”
Plast Reconstr Surg. 2004 Oct;114(5):1166-9
Tang Y, Luan J, Zhang X
Southern 2 Ward, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. firstname.lastname@example.org
Abstract: The rate of tissue expansion can be accelerated by papaverine through a special delivery system, according to an early report. Because the delivery system was complex and inconvenient, another means of administrating papaverine was tested to observe the rate of tissue expansion. In this study, 24 miniature pigs were divided equally into three groups. Four 150-ml silicone expanders were implanted into each pig in groups A and C. Four modified rectangular silicone expanders were also implanted into each animal in group B. During the expansion process, 1 g of 2% hydrochloride papaverine cream was applied topically onto the surface of each pig’s expanding skin in group A two times daily, and hydrochloride papaverine solution was injected into the outer shell of each modified expander in group B weekly. Group C acted as the control group. The mean sum of the first four times of saline water volume that was injected into the expanders was 142.42 +/- 5.6 ml in group A, 128.72+/-4.8 ml in group B, and 106.38+/-3.28 in group C. There were statistical differences among the three groups. The mean sum of volume saline water that was injected into hind expanders was 137.51 +/- 5.1 ml in group A, 120.35 +/- 3.6 ml in group B, and 102.63 +/- 4.76 ml in group C, and there was a statistical difference among the three groups as well. There was no statistically significant difference in the thickness of fibrous capsules among the three groups. This study shows that the rate of tissue expansion can be accelerated by topical application of papaverine cream, and the rate is better than the rate of tissue expansion induced by the special drug delivery system.
Slowly, but surely...
March '07: 6.875 BPEL x 5.0 EG
Now: 7.25 BPEL x 5.125 EG