You don’t think the studies done by the makers of Propecia are true? The pill, which inhibits the enzyme type II 5 alpha-reductase to decrease serum and scalp DHT, stops hair loss and helps in regrowth. It’s worked for me for several years now.
Okay I’ll bite. First I’ll explain the MPB angle, then bring it back on topic towards the end.
As you know, Test converts to DHT via 5-AR Type I and Type II. With Propecia it has been found that the MPB condition is improved with a partial antagonism of the Type II which I don’t think anybody would disagree with.
That said, I think it would be foolish to assume that because of the above it means that DHT and nothing else is causing hairloss. After all, if that were true then not only would nobody be losing hair, but we’d all be re-growing a thick full head of hair.
DHT damages the mitochondria in susceptible cells, which causes it to produce cytochrome C, which in turn promotes Capase 9 (and further downstream Caspase 3). DHT also promotes TGF-beta2 which is known to activate the newly released Caspases, and it is Caspase 3 in particular which is thought to cause apoptosis, or cell death.
So to prevent MPB we need to break that cycle in one or more places, and DHT is way back up the chain. Preventing Caspase 3 would be the ideal point if possible.
Getting slowly back on topic; a side effect of MPB is the high degree of fibrosis on the scalp around the follicle, so even when you partially block DHT with via 5AR-TypeII, or more completely via Type I&II, we still do not get good regrowth unless the MPB is fairly recent. Some people have experienced better regrowth with skin peels (to the point of bleeding scalps!).
If DHT promotes TGF which causes fibrosis, then it may be the case that when we PE, we are causing the very thing that prevents growth. It’s like the body has its own direct negetive feedback - not via downregulation but by physically shoring up the affected area. This is very effective for healing cuts and wounds, but not for PE.
So, I propose that we do not want to reduce DHT as it serves for us a useful growth role. What we want to do instead is take off the brakes that short circuit growth. I believe one of those angles in lowering the TGF family to moderate levels.
As an aside, it it known that women (who have less testosterone!) have better healing capabilities than men. In castrated men there is no marked difference. It is thought that the reason for this is not the testosterone itself (which promotes growth), but the TGF that it also triggers after DHT conversion.
If (if) Papaya/Bromelain help MPB, then by the very same axis they will likely help in PE. A key question is whether the body determines fibrosis to be an injury site or normal tissue, as that will probably determine whether it is of any use or not.
Hope that helps to explain the reasoning behind my earlier post.
Last edited by Shiver : 08-17-2004 at .