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IGF-1 as a supplement; not a miracle

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Originally Posted by ticktickticker
Goldmember - I agree that there will probably be no effect with systemic administration. That’s why I am suggesting intralig injections.

Stagestop - btw was doing intracavernous injections as far as I know to achieve prolonged erections. What happened to that man btw? I lost sight of hm completely.


I also think that intralig or intracavernous (better in my opinion) would be the very best way to test it out. Stagestop had a Chemical PE progress report going but it’s been a few months since he’s posted. Last I heard, he was trying to get 3-5 hour erections every other day from PGE-1 and added 20mcg of IGF-1 for added effect. He said 60mcg hurt like the Dickens, but 20mcg was very tolerable.


I love GOLD

Originally Posted by Doinitforlove
IGF-1 acts on several different tissues to enhance growth. IGF1 belongs in the ’superfamily’ of substances known as ‘growth factors,’ along with epidermal (skin), transforming; platelet derived fibroblast, nerve, and ciliary neurotrophic growth factors. None of the other factors have any bearing on exoskeletal tissue incidentally however These agents all have in common the ability to stimulate cell division, known as mitogenesis, and cell differentiation.”

Above is a snippet of info I noticed whilst looking at Revitropin (IGF-1 Long R3) on a site owned by a company called Neo Genica (just google search revitropin).

After doing a search on threads with IGF-1 mentioned I found that the general perception about its relation to PE was that it only stimulates muscular hyperplasia (an actual splitting of cells rather than a mere swelling or hypertrophy). The above quote I pasted seems to suggest otherwise.

Another quote,

“Every thing IGF1 touches will grow”

Now it’s certainly clear that it’s easy for me to highlight the more desirable sounding, claimed, effects and I can pretty much guarantee that those who read about it will notice some not so desirable side effects that comes with the drug. I’m also not simply saying “Take this wonder drug and without any other effort your unit will grow.” I would just like for a few of the members who are more experienced than me to cross examine the above quotes and still tell me that IGF-1 could never be utilised as an effective supplement to fully recover, repair and even help to split and create new cells within the anatomy of the penis after working out.

With a lot more research carried out by myself on this product I basically looking to inject this stuff as close to my dick as possible. The site suggests that you inject subcutaneously into the abdominal fat tissue. I was thinking more along the line of injecting it into the pubic bone fat pad.

Any views?

Thanks

I’ve already discussed this here somewhere. IGF is site specific for growth, but also has systemic effect. The MAIN issue with IGF is the acetic acid that is used to reconstitute the IGF-1. It BURNS like hell. And causes bruising and can cause necrosis of tissue.

I am using IGF-1, PEG MGF and GH as we speak.

My muscle growth is through the roof.

IF you plan on using IGF-1 take 50 MCG’s (notice that is MCG NOT mG’s which is miligrams) 3 times per week.

25mcg’s injected bilaterally into the shaft itself, BUT you must buy the kits that have 100mcg’s in each syringe because you can then reconstitute the IGF with bacteriostatic water and not AA.

Bottom line is IGF1 and PEG MGF (pegylated Mechano Growth Factor) both work to form NEW cells.

“From its sequence, MGF is derived from the IGF-I gene by alternative splicing and has different 3’ exons to the liver or systemic type (IGF-IEa). It has a 49 base pair insert in the human, and a 52 base pair insert in rodents, within the E domain of exon 5. This insert results in a reading frame shift, with a different carboxy (C) terminal sequence to that of systemic IGF-IEa. MGF and the other IGF isoforms have the same 5’ exons that encode the IGF-I ligand-binding domain. Processing of pro-peptide yields a mature peptide that is involved in upregulating protein synthesis. However, there is evidence that the carboxy-terminal of the MGF peptide also acts as a separate growth factor. This stimulates division of mononucleated myoblasts or satellite (stem) cells, thereby increasing the number available for local repair

During the early stage of skeletal muscle development, myoblasts (muscle stem cells) fuse to form syncytial myotubes, which become innervated and develop into muscle fibres. Thereafter, mitotic proliferation of nuclei within the muscle fibres ceases. However, during postnatal (after development) growth, additional nuclei are provided by satellite cells (myoblast) fusing with myotubules. Muscle damage-recovery seems to have a similar cellular mechanism, in that satellite cells become activated and fuse with the damaged muscle fibres (reviewed by Goldring et al. 2002). This is also pertinent to certain diseases such as muscular dystrophy in which muscle tissue is not maintained and which have been associated with a deficiency in active satellite (stem) cells (Megeney et al. 1996; Seale & Rudnicki, 2000) and in myogenic factors (Heslop et al. 2000). Skeletal muscle mass and regenerative capacity have also been shown to decline with age (Sadeh, 1988; Carlson et al. 2001). The reduced capacity to regenerate in older muscle seems to be due to the decreased ability to activate satellite cell proliferation (Chakravarthy et al. 2000). The markedly lower expression of MGF in older rat muscles (Owino et al. 2001) and human muscle (Hameed et al. 2003) in response to mechanical overload has been associated with the failure to activate satellite cells, leading to age-related muscle loss (Owino et al. 2001). Your muscle cels can not grow once they have reached a certain size unless they obtain more nuclei from the myoblast. MGF increases the myblast available to donate their nuclei to the adult muscle cell.
“MGF appears to have a dual action in that, like the other IGF-I isoforms, it upregulates protein synthesis as well as activating satellite cells. However, the latter role of MGF is probably more important as most of the mature IGF-I will be derived from IGF-IEa during the second phase of repair. Nevertheless, it has been shown that MGF is a potent inducer of muscle hypertrophy in experiments in which the cDNA of MGF was inserted into a plasmid vector and introduced by intramuscular injection. This resulted in a 20 % increase in the weight of the injected muscle within 2 weeks, and the analyses showed that this was due to an increase in the size of the muscle fibres (Goldspink, 2001). Similar experiments by other groups have also been carried out using a viral construct containing the liver type of IGF-I, which resulted in a 25 % increase in muscle mass, but this took over 4 months to develop (Musaro et al. 2001). Hence, the dual role MGF plays in inducing satellite cell activation as well as protein synthesis suggests it is much more potent than the liver type or IGF-IEa for inducing rapid hypertrophy.”

These results are based on actual transplantation of the DNA coding for the peptides. This is a permanent effect and much more potent than IM injections of the peptide itself. You will not see a 20% increase in muscle mass through IM injections as claimed above.

The PEGylated version is going to be much longer lasting making a 1-2 dose per week procedure possible. I still think its best used with IGF or AAS to maximize the benefits so here are some sample protocols

Once a week PEG MGF/ IGF
Sunday 100-300 mcg MGF you can choose to site inject if you wish. I think splitting large doses may benefit.
Monday –Fri IGF 50mcg e/d

Twice a week PEG MGF / IGF
Sunday and Wed MGF 50-150 mcg
MT, ThF IGF 50 mcg

http://www.ibeforums.com/portal/for…read.php?t=2558

Thethickone - any effect on your dick?

And where get the stuff (not in german pharmacies, unfortunately).


Later - ttt

Thethickone:

What is PEG MGF reconstituted in?

Is it possible to reconstitute IGF-1 in BA water, to avoid fibrosis and/or necrosis?

Have you looked into PGF-2a and/or TGF (transforming growth factor)?


I love GOLD

Originally Posted by ticktickticker
Thethickone - any effect on your dick?

And where get the stuff (not in german pharmacies, unfortunately).

Too soon to tell. It will take 6 months, but many bodybuilders report INCREASED GIRTH, but not length from taking GH.

Originally Posted by gold_member
Thethickone:

What is PEG MGF reconstituted in?

Is it possible to reconstitute IGF-1 in BA water, to avoid fibrosis and/or necrosis?

Have you looked into PGF-2a and/or TGF (transforming growth factor)?

PEG you can use BA, With IGF it is fragile so you need AA BUT if you use the 100MCG syringes you can use BA, but if you buy a 1milligram or 2 milligram vial you need via or the IGF will become unstable and the fragile amino sequence will disentigrate.

The sides for PGF-2a are too harsh for me to live with and is more for fat loss than growth, but if you need to shed some pounds it’s an incredible drug.

It does cause growth too maybe we should test it on animals. LOL
Some interesting stuff out there on this drug that’s for sure.

So you are saying that IGF-1 LR3 is stable for short periods of time in BA water, but if kept for extended periods of time, it should be reconstituted in acetic acid?


I love GOLD

Originally Posted by gold_member
So you are saying that IGF-1 LR3 is stable for short periods of time in BA water, but if kept for extended periods of time, it should be reconstituted in acetic acid?

Yes exactly. And 1 MILIGRAM is 20 doses even at 200micrograms a week that’s a month’s worth.

Cool. Thanks.


I love GOLD

Has anyone heard of pegylated MGF it is for new cell growth and it is not systematic. Has anyone injected this in their Wang. I am considering but want to see if one of the thunder brothers has attempted it.

http://www.pegmgf.com/home.htm

Originally Posted by thethickone
But if you need to shed some pounds it’s an incredible drug.

Could you please elaborate? How does one use it for that purpose?

Anybody?

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