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I thought this couldn't be true HGH causing growth

I take GH for life extension purposes mostly. I’ve experienced the typical effects, like reduced bodyfat, better sleep, better skin, improved cholesterol levels, etc.

Originally Posted by Touchmeifucan
Wrong.

General blood test is cheap even without insurance around $120 or so. You can get BRANDED EXTREMELY HIGH QUALITY HGH for $1.6/iu!

If ur going to run anything under 4iu FORGET IT!! YOUR WASTING YOUR TIME AND MONEY!!

And You can get 1000mcg of IGF LR3 for around $70. You only need 60mcg more or less is upto you but wouldn’t go over 100. IGF does cause more localised growth supposedly and ur body only produces 1mcg a day.

Your test price is about right though you can get it cheaper by a little more.

Wrong.

General blood test is cheap even without insurance around $120 or so.

A: The price of a blood test is going to vary on the lab and mostly upon which panels you run. I agree that you could run the basics for about that number, but I would want comprehensive metabolic profiles included (I.e. Full cbc, test, free test, “spirits” panel, thyroid panel, liver enzyme panel, among others). I think that’s the only responsible way to go.

You can get BRANDED EXTREMELY HIGH QUALITY HGH for $1.6/iu!

A: Maybe from a street dealer. But legally, from a legitimate doctor? Please tell me where, I’d be happy to save the money.

If ur going to run anything under 4iu FORGET IT!! YOUR WASTING YOUR TIME AND MONEY!!

A: I strongly disagree. Four of my friends are on 1 - 2 IU GH per day, 5 on 2 off. They have dropped bodyfat, improved cholesterol profile, improved appearance (wrinkles, hair) and FEEL GREAT! 4 IU may be a threshold dose for a bodybuilder, but for hormone replacement therapy (restoring levels to mid-normal range) is overkill.

And You can get 1000mcg of IGF LR3 for around $70. You only need 60mcg more or less is upto you but wouldn’t go over 100. IGF does cause more localised growth supposedly and ur body only produces 1mcg a day.

A: [For those that don’t know, IGF-1 is insulin like growth factor. It’s production is stimulated by HGH. IGF Long R3 is a synthetic derivative of IGF-1] Here is a nice quote about IGF Long R3 from the leading bodybuilding magazine:

“I was thinking about taking IGF-1 and wanted to know about safety. I have access to IGF-1 Long R3 [IGF LR3 as referred to by evangelionpunk, above]. Do you think this is a safe agent to take?”

Reply:

“I’ve known of a good number of bodybuilders to use IGF-1 Long R3 and the results were that the drug was generally very good. It is, however, important to point out that Long R3 is a synthetic derivative of IGF-1 and one that hasn’t yet been approved for human use in any country. It’s still an experimental agent, far from even human clinical trials. We have no placebo-controlled safety studies to make reference to and whatever is being said about it’s safety is either theoretical or anecdotal in origin.”


Last edited by freedman : 01-19-2007 at .

There is some clinical evidence that penile growth can occur in pre-pubescent boys who are administered HGH for medical reasons. How the body responds to this seems to vary with the individual, but I once saw a report that some boys had to be taken off the therapy because of excessive penile growth. Pituitary tumors can also cause similar effects with random body parts exhibiting excessive growth.

I wish I could find that report now, I saw it over a decade ago, in print not online, and it was about clinical trials of the old style HGH derived from human cadavers, not the modern synthetic variety.


"We have met the enemy, and he is us."

Freedman:

Even with those testing components(the test being the only one I didn’t consider) it should still only be around $230 odd dollars or so.

HGH point granted. From a doctor in the USA it’d be extremely expensive so why not buy it elsewhere and get it way cheaper? I mean if your seriously prepared to pay $8/iu why not pay 1.6 or so/iu and then you could run 4iu and still save money and that way you’d definitely see results.

Sure running 2iu or so more closely mimics your natural levels at optimal but it ain’t worth it IMO. Bodybuilders run doses as high as 20IU per day. 4iu is what people run to feel good, lose fat and look better etc. Where you’ll start running into any possible problems like extended gut is at around 8iu+ a day. Why not buy the cheaper HGH and run it at 4iu so you actually see results rather than think you may be seeing them etc.

Regarding IGF. People who don’t know and have no clue about the latest researches shouldn’t offer uneducated opinions.
IGF has been shown to do many things:
IGF has been shown to reduce protein degradation and enhances protein synthesis in skeletal muscle.
IGF enhances muscle hypertrophy and actually makes more cells(permanent growth).
And more and yes there have been human trials in some cases but so far very few. There’s much more data on lab animals such as rats etc than on humans.

One of the main reason HGH works so well for muscular growth and other bodyparts growth as due to increased IGF1 levels. There does need to be more studies done on IGF but all evidence points to increased muscle growth, bodyfat loss etc and so far I haven’t found any studies that have shown any side-effects on the doses administered.

The older, “real” HGH, that was derived from corpses, did actually enlarge the penis…the stuff now is synthetic, and does not.

GH can cause a size increase in someone’s jaw, head (on their shoulders), etc.

I wouldn’t use it unless you know EXACTLY what you are doing.

Originally Posted by Touchmeifucan
Freedman:

Regarding IGF. People who don’t know and have no clue about the latest researches shouldn’t offer uneducated opinions.
IGF has been shown to do many things:
IGF has been shown to reduce protein degradation and enhances protein synthesis in skeletal muscle.
IGF enhances muscle hypertrophy and actually makes more cells(permanent growth).

Indeed, most of the benefit from HGH seems to be from increased IGF-1 levels, as you point out later in your post. But there’s a difference between IGF-1 and IGF LR3, a synthetic derivative, and it’s just too early, IMO, to judge the safety of LR3 for human use (which isn’t to say that it’s not an incredibly effective drug, it is).

Respectfully, my opinion on LR3 isn’t uneducated. I have never found any abstracts on human clinical trials. If I’ve missed them, which is not outside the realm of possibility :-) , please pass them along I would love to read them.

No probs freedman. Do a search on pubmed and you’ll find them.

Only difference between IGF1 and IGF1 LR3 is that lr3 lasts longer both reconstituted and within the body unlike igf1.

Chuckyup HGH is HGH. Cadaver or not doesn’t make a difference in it’s effectiveness nor it’s effects.

Shympls hgh can lead to those things yes but not within reasonable limits of 1-4,5,6iu a day. It’s when you push the boundaries too far as in 20iu etc when your asking for gigantism and other things.

HGH differences

Chekyup- actually, not all HGH is identical. First, it is important to note that cadaver HGH is no longer used because it’s use was linked to Creutzfeldt-Jakob disease.

This leads us to biosynthetics (rHGH), of which there are two main varieties:

1. 192 Amino Acid Sequence HGH (Somatrem): Inclusion Body technology was the first biosynthetic form of HGH developed (known as Met-GH, Somatorm or 192 amino acid sequence HGH). When researchers first developed HGH using Inclusion Body Technology, they were comparing it to cadaver-GH. However, Met-GH was not pure GH, so met-GH produced side effects in many users. Met-GH has an additional methionyl amino acid that caused a person’s body to build up antibodies against it. Some users experienced allergic reactions to met-GH, some even built up so much resistance that it neutralized the effect of the drug.

Currently manufactured examples of this drug are: Ansomone (made by AnkeBio), Tev-Tropin (made by TEVA Pharmaceuticals), and Fitropin (made by Kexing).

2. 191 Amino Acid Sequence HGH (Somatropin): The method of manufacturing HGH that is most often used now is through either Protein Secretion technology or Mouse-cell technology. Both of these means of manufacturing create HGH that is identical to the GH produced naturally in a human body.

Currently manufactured examples of this drug are: JinTropin (GeneScience Pharmaceuticals), Nutropin (Genentech), Genotropin (also Genentech), Humatrope (Eli Lilly), Saizen (Serono), Serostim (also Serono), Zorbtive (Serono again), Norditropin (Novo Nordisk), Zomacton (Ferring Pharmaceuticals).

IGF-1 / IGF-1 LR3 differences

IGF Long R3 is IGF-1 which has been chemically altered and has had amino acid changes which cause it to avoid binding to proteins in the human body and allow it to have a much longer half life, around 20-30 hours.

Long R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence
With the substition of an Arg(R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus.

This analog of IGF-1 has been produced with the purpose of increasing the biological activity of the IGF peptide.

The following is piecemeal from a column in Muscular Development and provides interesting information on dosing/efficacy/side effects:

However, what bodybuilders started noticing after extended usage of Long R3 IGF-1 was that it stopped working as effectively after about 4 weeks.

Moreover, as the dosage of IGF-1 increases above the suggested 10-20 mcg per day, the IGF-1 muscle cell receptors become saturated and now all this excess IGF-1 goes straight to the highest naturally occuring concentration of IGF-1 receptors - the extremities (I.e feet, hands and facial bones).

Thereby, side effects such as shoe and hand size increases and facial bone thickening can occur. Additionally, high Long R3 IGF-1 dosing will lead to decreases in muscle cell IGF-1 receptors, thus diminishing the results seen with Long R3 IGF-1 usage over time.

In summation, empirical evidence has shown that 10-20mcg per day of Long R3 IGF-1 causes significant muscle cell hyperplasia and will continue to do so extremely effectively for approximately 30 days.

However, even with conservative amounts of Long R3 IGF-1, the hormone still stops functioning after a period of time.

Ultimately the author recommended short cycles of low doses of the drug with frequent holidays, and the magazine also states that it’s human safety is still undetermined.

I’m not poo-pooing anybody, just remember to be careful and do your research on these things, especially with dosing and duration; facial bone thickening is not a reversible side effect.


Last edited by freedman : 01-20-2007 at .

Good work freedman.

Looks like some nice cut and paste job :) and people should understand the basics.

IGF1-LR3 is run in cycles lasting no more than 1month. Then you take time off and run again.

Many people try and avoid every day injections and super saturation of the muscle receptors hence it’s common to run IGF ONLY on training days or every other day or training days higher doses and rest days low dose.

Also note that theres a ton of generics both for HGH and IGF mainly manufactured in China which leads to substantial savings over those named brands you stated above.

192s main problem was antibodies rejection and hence allergic reaction to it in SOME people and as a consequence now almost all brands and generics are 191.

Oh come on, you did know this ? It’s common knowledge .j/k

I think it’s medically foolish to try this on youself.,

Does the body down regulate it’s own production of HGH and/or IGF-1 in the presence of external sources? I ask because I understand this happen to a large degree with T replacement therapy — when a guy take Androgel or is administered T in whatever other form to bring their levels up to normal range, the body actually shuts down it’s own T production, so you are left entirely with the non-native T. This is also the case with anabolic steroid users like bodybuilders, baseball players (heh), etc. — When they take steroids for a certain length of time, coming off of them is difficult because their body is no longer producing it’s own anabolic hormones.

Does the body down-regulate it’s own production of HGH or IGF-1 in an analogous manner?

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