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Glisodin - Essential for all clampers?

Glisodin - Essential for all clampers?

For clampers and other members who use manual exercises used to increase engorgement, you may be interested in a compound called glisodin. It’s doubtful that it will help increase gains but it should help increase safety and prevent cell death or damage that may otherwise occur.

Whether you keep your set times or constriction low, or go for longer and more extreme types of clamping, one possibility is reperfusion injury. I have seen this talked about many times at Thunder’s before but if you have not heard of this here is a summary.

Reperfusion injury refers to damage to tissue caused when blood supply returns to the tissue after a period of ischemia. The absence of oxygen and nutrients from blood creates a condition in which the restoration of circulation results in inflammation and oxidative damage through the induction of oxidative stress rather than restoration of normal function.

Most clampers aim to block outflow and not inflow, so a true ischemia is likely not much of an issue, but we are certainly disrupting the natural inflow/outflow of blood and I believe that damage could still be occuring for some of us even if it’s small and causes no perceptible problems.

Now here is some information on Glisodin:

Glisodin, a dietary supplement derived from superoxide dismutase (SOD) and wheat gliadin, has been studied for its ability to mitigate ischemia-reperfusion injury. A study of aortic cross-clamping, a common procedure in cardiac surgery, demonstrated a strong potential benefit.

Even if you feel it will have no benefit to your PE career it might be a great addition for anyone looking for a great antioxidant that has been clinically shown to do so many beneficial things for the body. Here is a link to benefits and studies on Glisodin. It’s seems to be a very impressive compound with some great potential benefits.…nces%204.07.pdf

Then: 5.63"x4.25" ---> Now: 6.50"x4.44"

This is a very thoughtful post. Perhaps it might have some benefit for vascular health but I don’t know if one could obtain it as a supplement.

However, (being in the field and acquainted with reperfusion injury) I believe reperfusion injury is almost certainly not an issue when your talking about clamping, which is done for usually 10 min. Even 20 min. with that blood volume wouldn’t be significant - in regard to reperfusion injury. What is more of a concern with clamping is the venous stasis that can lead to thrombosed veins or capillaries. This is why you have to pay attention to time and color.

But it couldn’t hurt to have some more anti-oxidants, preferrably from natural sources like berries and fruits.

Thanks for your input. I thought the chances of a reperfusion injury was low as most/all of us are not causing ischemia while clamping but I hadn’t seen any mention of this supplement yet on the forum even after searching so I thought it’d be good to let the forum know about it. I have started taking this due to many of the other benefits it can give, although I do eat lots of fruits and vegetables as well.

Then: 5.63"x4.25" ---> Now: 6.50"x4.44"


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