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Chemical PE: The Long Awaited Evidence

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Originally Posted by london100
I am considering injecting VEGF and IGF along with my PGE.

These substances are actually available from research suppliers. There is evidence that they can increase SM content in mice.

My theory rests on the assumption that SM enlargement will force the tunica to expand.

I can’t find any evidence either way about this. Although there is evidence that SM shrinkage will force the tunica to shrink.
“Penile length changes after radical prostatectomy”

How many hours do you think it would be good for you to have an erection with all these drugs injected ?


Starting stats: 6.4" / 5.6" Current Stats: 7.4" / 5.8" Short term goal: 7" / 6" Long term goal: 8" / 6.5"

I’m not sure. I would probably go for an extremely conservative dose to begin with.

The erections would be on-off

I am considering injecting VEGF (since I will be injecting my penis, I figure I might as well). This has been shown to radically increase smooth muscle content in animals. It is not a controlled substance and appears to be readily available from research suppliers. It is released by the body in response to hypoxia and could potentially be the reason why some men with priapism experience massive growth.

Originally Posted by london100
could potentially be the reason why some men with priapism experience massive growth.

Do you have a reference for this phenomenon. I have not come across this situation. I always read that priapism lead to damaged cells.

If testosterone supplementation (even at mad dosis) doesn’t enalrge the penis, how could VGEF alone lead to enlargement?

Maybe if you would just do what is known instead than dreaming about doing the amateurish mad doctor you could have gained some girth in the meanwhile.

Originally Posted by marinera
If testosterone supplementation (even at mad dosis) doesn’t enalrge the penis, how could VGEF alone lead to enlargement?

Maybe if you would just do what is known instead than dreaming about doing the amateurish mad doctor you could have gained some girth in the meanwhile.

That study posted by Cya at 8 made a very strong case against T derivatives.
T is a controlled substence, which means that you have to buy from a drug dealer. The risks of getting an adulterated product would be too large.

You are not understanding. Testosterone dramatically raises VGEF levels AND has other growth-boosting actions; neverthless, it doesn’t enlarge the penis of healthy subjects. So, even less likely VGEF injections alone can enlarge the penis.

Originally Posted by marinera
You are not understanding. Testosterone dramatically raises VGEF levels AND has other growth-boosting actions; neverthless, it doesn’t enlarge the penis of healthy subjects. So, even less likely VGEF injections alone can enlarge the penis.

Can you provide more info?

There does appear to be evidence that T boosts VEGF in the prostate.

I cannot find any evidence that it does this in the penis.

This VEGF idea is still at the drawing board stage. Its just something that I thought I’d throw out there.

I am basing my idea on this:

“Intracavernosal Injection of Vascular Endothelial Growth Factor Improves Erectile Function in Aged Rats”

Results: After 4 weeks of treatment, the ratio of peak intracavernosal pressure to systemic arterial blood pressure in response to neurostimulation was significantly higher in both the VEGF 1 μg/kg (79.9 ± 7.7%) and the VEGF 10 μg/kg group (76.8 ± 5.8%) compared to the vehicle-only group (63.1 ± 8.5%; p < 0.05). The percentage of cavernosal smooth muscle was significantly higher in the VEGF 10 μg/kg group (16.1 ± 1.4%) compared to the vehicle-only group (12.8 ± 2.2%; p = 0.047). VEGF treatment in old rats increased e-NOS and VEGF expression in both treatment groups.

Conclusion: Intracavernosal injection of VEGF appears to restore smooth muscle integrity and improve erectile function in aged rats.

http://www.europeanurology.com/arti…0278-7/fulltext

One - in hurry.

“Effects of androgen on the expression of vascular endothelial growth factor in the penile corpus cavernosum.
Hwang EC, Oh KJ, Jung SI, Kim NN, Ahn KY, Park K.
Source

Department of Urology, Chonnam National University Medical School, Gwangju, Korea.
Abstract
OBJECTIVES:

To investigate the effect of orchiectomy and androgen replacement on the expression of vascular endothelial growth factor (VEGF) in rat penile tissue.
MATERIAL AND METHODS:

Adult male Sprague-Dawley rats (12 weeks old) were left intact (control) or surgically castrated. Orchiectomized rats were left untreated or received testosterone propionate (TP) for 7 days, beginning 1 or 2 weeks after castration. Erectile function was assessed by measuring intracavernosal pressure in response to cavernous nerve stimulation, and the expression of VEGF protein and mRNA was determined by immunohistochemistry, Western blot analysis, and reverse transcriptase-polymerase chain reaction. Serum testosterone values were measured in each animal by radioimmunoassay.
RESULTS:

Serum androgen levels decreased significantly in castrated animals, whereas TP injection normalized the serum levels of testosterone. Intracavernosal pressure was significantly decreased in untreated castrated rats (31.3 ± 15.7% at 2 weeks postcastration; 18.6 ± 4.6% at 3 weeks postcastration) compared with intact controls (58.0 ± 11.4% and 58.9 ± 8.2%, respectively). Erectile function was normalized in androgen-replaced rats, irrespective of treatment was initiation 1 or 2 weeks after orchiectomy. The expression of VEGF protein and mRNA was decreased in the corpus cavernosum of castrated animals compared with controls, whereas androgen replacement normalized the expression of VEGF. These results were consistently observed by all 3 methods of assessment.
CONCLUSIONS:

These data suggest that androgen regulates the expression of VEGF in rat penile corpus cavernosum and confirms the importance of androgens in the maintenance of erectile function.”

http://www.ncbi.nlm.nih.gov/pubmed/21458034

You can find by yourself other literature, I’m sure.

Good point.

In this study they castrate rats and the VEGF concentrations go down. They give the rats T and VEGF goes back up to the normal rate.

However, this does not necessarily mean that megadosing with T will provide higher than normal concentrations of VEGF.

I will read up on this further.

Originally Posted by london100
The following references are about a phenomenon called “megalophallus”, a rare side effect of priapism
There are occasional references to general “enlargement” in the literature


The referenced material covers one case of one individual who encountered 69 episodes of priapism over many years stemming from his sickle cell disease. A number of his priapism episodes lasted for several days.

Apparently, hypertrophy occurred in his CC as a result of the many long lasting episodes of parapism, some up to four days.

I personally would not want to go through this process to enlarge my penis.

Originally Posted by dtwarren1942
The referenced material covers one case of one individual who encountered 69 episodes of priapism over many years stemming from his sickle cell disease. A number of his priapism episodes lasted for several days.

Apparently, hypertrophy occurred in his CC as a result of the many long lasting episodes of parapism, some up to four days.

I personally would not want to go through this process to enlarge my penis.

There are only five documented cases of this as far as I am aware.

I obviously would not want to suffer priapism.

The idea is to try and experience something similar without the negative side effects.

Two cases seems to be the same case, actually. And at least in one of the cases you linked, the guy earned an erectile disfunction.
Actually, erectile disfunction and penile irreversible damage is a way, wayyyyy more likely consequence of priapism.

Out of curiosity, did you know that the biggest case (as far as size) of megalophallus reported derived from, basicaly, natural PE? And without erectile disfunction as a consequence. I think I linked the article in the PE Science thread, give it a read.

Originally Posted by marinera
Two cases seems to be the same case, actually. And at least in one of the cases you linked, the guy earned an erectile disfunction.
Actually, erectile disfunction and penile irreversible damage is a way, wayyyyy more likely consequence of priapism.

Out of curiosity, did you know that the biggest case (as far as size) of megalophallus reported derived from, basicaly, natural PE? And without erectile disfunction as a consequence. I think I linked the article in the PE Science thread, give it a read.

Please post the article!!!

I have read through the thread I think your refering to. I don’t remember coming across anything like that.

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