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Chemical PE: Animal Testing

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The human body contains roughly five litres of blood. The concentration of VEGF in the blood varies massively (155 ± 110 pg/ml). This implies that the average person has roughly 775 000 pg of VEGF in their body. A 1ml injection of VEGF at three times blood concentration would raise systemic concentration by 310 pg. That represents an increase of 0.04 percent. That is very unlikely to do any systemic damage.

155 ± 110 pg/ml implies that it is fairly common for people to have 35 percent higher VEGF concentrations than the general population and remain healthy.

http://journals.lww.com/plasreconsu…lysis .19.aspx

Originally Posted by carrotsrorange
London, you can confidently walk on the street knowing that you are larger than most men you see including those on this forum. Although I am all for PE research, (search for my thread called ‘an academic’s perspective’) the reasons you are doing it for are baseless and the experimental methodology you described not sensible. Is he going to give his dog and erection?

If you want to fund a study involving PE, figure out a way to design an experiment that figures out why people have such diverse results with PE.(excluding a bias of bad technique).

This thread is simply crazy.

The researcher would give the dog an erection by injecting it with pge-1 and measure size changes using callipers. I assumed that the anatomy of a dog’s penis was pretty much the same as that of a human. I have just discovered that dogs have bones in their penises. That would probably make the experiment inapplicable to humans. I never claimed to be the brightest bulb in the tanning bed, but at least I am open-minded and willing to learn.

The theory behind this is not baseless. I have just sent an email to a penis enlargement clinic in India asking for advice (I paid $300). The email that I sent sums up what I think about the wonderful world of CPE:

………………………………………….. …………

Dear Sir,


I am a student from the UK. I am extremely insecure about the size of my penis. This is more of a psychological condition than a physical one. My penis size is above average.

A Canadian doctor named Kenneth Adams took out a patent on a new form of penis enlargement.[1] He began treating clients with this technique, which was based principally on megadoses of erectile dysfunction meds such as Alprostadil. He continues to offer this service, but is taking on no new clients. There is also anecdotal evidence to be found on the internet of people using megadoses of filtered research grade PGE-1 and achieving substantial enlargement. The aim of this treatment is to simulate high-flow priapism: a condition that is very occasionally associated with massive enlargement without loss of potency.[2] There is evidence that megadoses of Papaverine can induce smooth muscle hypertrophy in primates.[3] I contacted a researcher who performed one of these studies and asked him if an increase in penis size took place. To my surprise, the researcher, who is a professor of urology, informed me that a visible enlargement took place. Do you think that megadoses of ED drugs could induce enlargement? What is your professional opinion on the safety and efficacy of this form of treatment? Have you tried this treatment at your clinic?

An American doctor named Charles Runels offers a service called the ‘priapus shot’.[4] This involves the injection of platelet-rich plasma (PRP). The doctor charges $1,900 for a single shot. I am reliably informed that this treatment is totally ineffective. The concentration of VEGF and other important growth factors in PRP is roughly three times higher than in normal blood. VEGF has been shown to radically increase smooth muscle content in animals.[5] A single shot can increase smooth muscle content by around 10 percent. (The results are not always statistically significant because of the high standard deviations.) VEGF has been touted as a potential cure for various forms of ED, but human trials have not yet been attempted. The penis is roughly 50 percent smooth muscle. Is it reasonable to presume that a 20 percent rise in smooth muscle content would result in a 10 percent rise in penile volume? Would it be theoretically viable to inject VEGF at three times blood concentration over the course of several months in the hope of enlargement?

Regards,

xxx

[1] http://patft.uspto.gov/netacgi/nph-…22&s2=adams&OS=

[2] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571870/

[3] http://www.ncbi.nlm.nih.gov/pubmed/3669186

[4] http://runels.com/growpenis/index.html

[5] http://www.ncbi.nlm.nih.gov/pubmed/12605238

Do us a favor, would you?

If you want to do bizarre experiments on animals (and what you are suggesting is bizarre), how about trying this on yourself, being your own guinea pig?

I’ve got two dogs (as well as a lot of other animals). No matter what amount of money you offered would get me to do what you are suggesting.

Here is how I feel: You keep this up, at our site, and I will do my best to see that you are removed from this building.

There are other ways to find out what you want to know.


_______________

avocet8

Originally Posted by avocet8

Do us a favor, would you?

If you want to do bizarre experiments on animals (and what you are suggesting is bizarre), how about trying this on yourself, being your own guinea pig?

I’ve got two dogs (as well as a lot of other animals). No matter what amount of money you offered would get me to do what you are suggesting.

Here is how I feel: You keep this up, at our site, and I will do my best to see that you are removed from this building.

There are other ways to find out what you want to know.

You beat me to it avocet. If he is so convinced it’s all harmless, he should try it on himself.

Originally Posted by london100
I am extending my offer to anybody with a non-neutered pet dog. I would supply all the growth compounds for free. I would pay $500 dollars for photographic evidence of the experiment being carried out. You would obviously have to anaesthetize the dog before injecting. The animal would not suffer.

Please don’t respond to this post by attempting to make fun of me. I am seriously considering carrying this out on myself. I want to be pretty damn sure that this is (a) effective and (b) safe before trying it out on myself.

You would also have to inform me that you had obtained legal permission to do this or lived in a country without such laws.

london,

I have had about enough of your animal testing crap. Keep it up and you will be shown the door.


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