The human body contains roughly five litres of blood. The concentration of VEGF in the blood varies massively (155 ± 110 pg/ml). This implies that the average person has roughly 775 000 pg of VEGF in their body. A 1ml injection of VEGF at three times blood concentration would raise systemic concentration by 310 pg. That represents an increase of 0.04 percent. That is very unlikely to do any systemic damage.
155 ± 110 pg/ml implies that it is fairly common for people to have 35 percent higher VEGF concentrations than the general population and remain healthy.