Chemical PE: Animal Testing

P.s I’ll echo what others had said though, you’re penis is big compared to the UK average!

I’d shoot someone to have a penis your size. I’m currently 5.5” BPEL.

Try that for size.

There are compounds (such as interluekin) that have been shown to upregulate androgen receptors. It is therefore theoretically possible to engineer a ‘second puberty’ in the dick.

There are compounds (such as VEGF) that have been shown to radically increase smooth muscle content. There are animal studies showing that a single shot of this substance can boost smooth muscle content by 20 percent. (the results are not always statistically significant because of the high standard deviations). The penis is 50 percent smooth muscle. It is therefore theoretically possible to induce a 10 percent rise in penile volume with a single shot.

The ‘chronic papaverine’ study (see my other thread) demonstrates that chronic use of ED meds can result in visible size increases.

Animal experimentation could tell us in a matter of months what works. This would not only allow the CPE enthusiasts on this site to strut around like pornstars. The information obtained could be worth a lot of money. A bigger dick is something desired by approximately half of the human beings on this planet. If we designed a successful protocol it would be fairly easy to commercialise. There are already hormonal penis enlargement clinics in India. These Indian doctors make good money selling what is generally a totally useless product. Imagine how much money could be made from selling a product that actually worked for the average man.

London, doctors are already doing this with humans. I saw a study where this guy ran a clinic (is was all on this website) and all of his patients went through 2-5 hour erects like three times a week, along with IGF, testosterone, etc and they almost all gained apparently. Have you not seen this?

And if VEGF does that and fits through a small needle, show me a study where it says it’s safe and fits through a small needle, I’ll fucking test it for you.

Are you referring to the Dr Adams patent? The supposed gains were way beyond what could reasonably be expected. Although, Ronielle followed a similar protocol and apparently experienced extraordinary gains. I am a not too sure about that whole thing.

VEGF is relatively cheap. Numerous animal studies have been performed. None of the animals showed evidence of disease. It is currently being considered as a future treatment for erectile dysfunction, but human trials have not yet been attempted.

Platelet Rich Plasma (PRP) contians VEGF at roughly three times blood concenration. PRP has been a maistreem treatment for two decades. There is no evidence that PRP causes cancer or any other disease.

London, I’m curious what you think about Ronniele’s experience with cpe. Why would you just not pay him for a consult since he seems to be doing experiments on himself?

He is actually planning to inject VEGF and some other compounds at some stage in the future. He claims to have already experienced massive gains (5*7 inches to 7*9 inches). His testimony will be interesting, but I am looking for someone who more closely approximates my own situation.

I have spoken to Ronielle seven or eight times on the phone. I personally believe that he has experienced substantial gains, but I cannot be sure. He may have some sort of genetic predisposition towards extraordinary gains (similar to those priapism patients who inexplicably end up with megalophallus).

I am extending my offer to anybody with a non-neutered pet dog. I would supply all the growth compounds for free. I would pay $500 dollars for photographic evidence of the experiment being carried out. You would obviously have to anaesthetize the dog before injecting. The animal would not suffer.

Please don’t respond to this post by attempting to make fun of me. I am seriously considering carrying this out on myself. I want to be pretty damn sure that this is (a) effective and (b) safe before trying it out on myself.

You would also have to inform me that you had obtained legal permission to do this or lived in a country without such laws.

But dog has bone on his penis.

So you think that the dog would more closely approximate your situation than Ronnielle?

That is a good point. I actually never knew that. You learn something new every day. Maybe this is not such a good idea.

London, you can confidently walk on the street knowing that you are larger than most men you see including those on this forum. Although I am all for PE research, (search for my thread called ‘an academic’s perspective’) the reasons you are doing it for are baseless and the experimental methodology you described not sensible. Is he going to give his dog and erection?

If you want to fund a study involving PE, figure out a way to design an experiment that figures out why people have such diverse results with PE.(excluding a bias of bad technique).

This thread is simply crazy.

"POEMS syndrome: definitions and long-term outcome
Presented in abstract form at the 41st annual meeting of the American Society of Hematology, New Orleans, LA, December 3-7, 1999.

Angela Dispenzieri,
Robert A. Kyle,
Martha Q. Lacy,
S. Vincent Rajkumar,
Terry M. Therneau,
Dirk R. Larson,
Philip R. Greipp,
Thomas E. Witzig,
Rita Basu,
Guillermo A. Suarez,
Rafael Fonseca,
John A. Lust, and
Morie A. Gertz

……….
Pulmonary hypertension, renal failure, thrombotic events, and congestive heart failure were observed and appear to be part of the syndrome. In 18 patients (18%), new disease manifestations developed over time.
…………….
We conclude that the median survival of patients with POEMS syndrome is 165 months, independent of the number of syndrome features, bone lesions, or plasma cells at diagnosis
………………

Preliminary data suggest that vascular endothelial growth factor is an excellent candidate as a pathogenic factor in POEMS29 30; it induces a rapid and reversible increase in vascular permeability, is a growth factor for endothelial cells, and is considered important in angiogenesis.27………."

http://bloodjou rnal.hematology … 101/7/2496.full

Ophthalmology. 1996 Nov;103(11):1820-8.
Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate.
http://www.ncbi … /pubmed/8942877

Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate.
http://www.ncbi … /pubmed/8694732

Intravitreal VEGF and bFGF produce florid retinal neovascularization and hemorrhage in the rabbit.
http://www.ncbi … pubmed/11402391

Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primates.
http://www.ncbi … /pubmed/9227268

Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

Abstract

Multiple myeloma (MM) remains incurable, with a median survival of 3 to 4 years. This study shows direct effects of vascular endothelial growth factor (VEGF) upon MM and plasma cell leukemia (PCL) cells. The results indicate that VEGF triggers tumor cell proliferation via a protein kinase C (PKC)–independent Raf-1–MEK–extracellular signal-regulated protein kinase pathway, and migration via a PKC-dependent pathway. These observations provide the framework for novel therapeutic strategies targeting VEGF signaling cascades in MM.

http://bloodjou rnal.hematology … t/98/2/428.long

God Damn Dog Dick Dicklers, Batman!