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Big problem with Cabergoline

Big problem with Cabergoline

By Gene Emery and Toni Clarke Thu Jan 4, 8:21 AM ET

BOSTON (Reuters) - Two Parkinson’s disease drugs cause the same kind of heart damage that led to the withdrawal of the diet drug combination “fen-phen,” according to two studies published on Wednesday.
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Patients taking the drugs pergolide, developed by Eli Lilly & Co. and sold under the brand name Permax, and cabergoline, developed by Pfizer Inc. and sold under the brand Dostinex, had a sharply higher risk of heart valve damage than those taking other therapies, the studies said.

The studies, one of which analyzed the records of 11,417 patients in Britain and one of which tested 245 patients in Italy, reinforce the results of earlier, smaller studies showing drugs that activate a cellular receptor known as 5-HT2b can cause damage to the heart valve, a serious condition that can lead to heart failure and sudden death.

“We recommend that physicians not prescribe drugs that have this biochemical property,” said Bryan Roth, a researcher at the University of North Carolina, Chapel Hill, who was not involved in the trials, but viewed the data and commented on it in The
New England Journal of Medicine, where both studies appeared.

Michael Berelowitz, a Pfizer senior vice president, said cabergoline has very modest sales and is only approved in the United States for hyperprolactinemia — a condition in which excessive amounts of the hormone prolactin enter the bloodstream due to benign tumors of the pituitary gland.

He said benefits of the Pfizer drug, which is sold in Europe for Parkinson’s disease, as well as hyperprolactinemia, outweigh the increased risk of heart valve damage, which is noted in the drug’s package insert label.

Lilly officials could not immediately be reached for comment.

Such drugs also include the migraine headache drug ergotamine and the amphetamine derivative known as “ecstasy.”

Roth said his team, in a separate piece of research that has yet to be published or reviewed by the scientific community, has identified several other big-selling drugs that have until now not been known to activate the 5-HT2b receptor.

He declined to reveal the names of the drugs until the research has been published.

“We recommend that every drug be screened at this receptor before it goes into humans,” Roth told Reuters in an interview. “It costs just pennies per drug for such a screen.”

The British study showed patients taking pergolide were 7.1 times more likely to develop heart valve damage than those who took other treatments. Patients taking the highest doses of the drug had a 37 times greater risk.

The study showed patients taking cabergoline were 4.9 times more likely to develop heart valve damage. At higher doses patients were 50.3 times more likely to suffer damage.

Both drugs are available in generic form.

A second study, conducted in Italy, tested 245 people, of whom 155 had Parkinson’s disease. Of the diseased population, one group received pergolide, one group received cabergoline and one group received an alternative Parkinson’s treatment. The non-diseased control group received nothing.

The results showed that 23.4 percent of patients taking pergolide and 28.6 percent of patients taking cabergoline suffered heart damage, compared with just 5.6 percent in the control group.

“These are huge risks,” said Roth.

He added they were similar to the kind of damage seen with fen-phen, whose main ingredients were withdrawn in 1997 and forced the drug-maker Wyeth to take more than $21 billion in charges to cover liabilities.

Wyeth’s recalled drugs were fenfluramine, or Pondimin, and dexfenfluramine, or Redux. To make fen-phen, one or the other was combined with another drug called phentermine that is still sold by other companies.

Wyeth, then called American Home Products, recalled Pondimin and Redux after some of the 6 million Americans who had taken fen-phen developed heart-valve problems.

Roth said pergolide is also used to treat restless leg syndrome, a condition in which patients feel a crawling sensation in their legs combined with a need to move them.

(Additional reporting by Ransdell Pierson in New York)

I had read this as well. I have used cabergoline a few times. I felt it’s sexual use, namely lessening the refractory period, was noticeable, but not significant. Certainly not a big enough benefit with the risks mentioned above.

Yeah I also stopped taking it. I would give it mixed results and not worth the risk.


I haven't failed, I've found 10,000 ways that don't work. Thomas Edison (1847-1931)

Wow, thanks for posting this. I bought some about 3 weeks ago, and now rather unhappy at wasting my money.

I got no benefit from the stuff and I took it for about two months.

Cabergoline? Great stuff.

It would be of no use to a young man though. The benefit from prolactin being inhibited is only apparent as we get older. If you are 20, can bust a nut, wipe it off, stay hard, and keep going then reducing your nearly nonexistent prolactin level is of no value. If you are older, cum then go soft it would be more beneficial.

It’s not a “get hard” drug, it’s more of a stay hard drug. Beneficial to older guys. About the other risks, wow they sound pretty serious. Some questions for the ones that got it and aren’t happy with the results. Are you too young for it to be of any use? Is there something besides prolactin keeping you from being able to “keep going”? Did you get real stuff or did you get scammed? Sadly, there are a lot of scammers out there selling fakes when it comes to so many medications.

Do I want to live a long time and NOT have a great sex life? No way. Personally, I’m willing to give up a few years to have my remaining years be good ones. I may not have that much time left anyway though so my perspective may be a bit skewed on the matter.

Originally Posted by baywatch
I got no benefit from the stuff and I took it for about two months.

Same here. I took it for about 4 months I guess.

Same here

Gave it a try. Nothing positive but some significant negative side effects. MXL

Originally Posted by viroid
Patients taking the drugs pergolide, developed by Eli Lilly & Co. And sold under the brand name Permax, and cabergoline, developed by Pfizer Inc. And sold under the brand Dostinex, had a sharply higher risk of heart valve damage than those taking other therapies, the studies said.

The recent studies suggest that there is little risk at the dosages most of us would take this at. For Parkinsons and excess prolactin, the doages are 2-6 mg daily. We usually take .025 mg weekly.

Originally Posted by trainr

The recent studies suggest that there is little risk at the dosages most of us would take this at.

Can you link to any study that shows specifically that cabergoline does not pose a risk to heart valve damage at any dose?

In this study, severity of valve damage is correlated with size of dose, but that does not mean there is a ‘safe’ dose.

http://www.medscape.com/medline/abstract/17202454

Quote
We usually take .025 mg weekly.

Who is we?

Does that size dose give you any positive effect?

Originally Posted by littlehobo

Do I want to live a long time and NOT have a great sex life? No way. Personally, I’m willing to give up a few years to have my remaining years be good ones. I may not have that much time left anyway though so my perspective may be a bit skewed on the matter.

There are non ergot derived dopamine agonists that are used for similar purposes, that do not come with the risk of heart damage. You may not have to choose between a great sex life and a long and healthy life. Look up ropinirole and pramipexole.

I haven’t heard anything about these drugs in reference to sexual enhancement, but considering they are dopamine agonists used for Parkinsons, and also inhibit prolactin, they might be a good alternative.


Horny Bastard

Have you heard of the herb mucuna puriens? Apparently it works similarly to cabergoline.

Levels appropriate for the treatment of Parkinson’s disease and in some studies you have upped you chance of having cardiac valvular abnormalities. But in low doss usage such as for the treatment of hyperprolactinaemia, (or recreationally/sexually), no damage to the heart has been documented.

A very short pdf letter that cuts to the chase.
http://www.aace.com/newsroom/inthen…cabergoline.pdf

Clinical trials.
http://clinicaltrials.gov/ct2/show/…oline%22&rank=3

Interesting forums. They discuss the same blood pressure thing that Dino experienced.
http://pituitarychatfriends.multipl…urnal/item/2678

More links, come of it redundant.
http://www.eje-online.org/cgi/conte…tract/159/4/R11

http://www.endocrine-abstracts.org/…/ea0015p219.htm

http://www.biomedsearch.com/nih/Lon…t/18594989.html

http://www3.interscience.wiley.com/…ETRY=1&SRETRY=0

http://jcem.endojournals.org/cgi/co…full/93/12/4643


Running a Massive Co-Front.


Last edited by iamaru : 01-01-2010 at .
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