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Acetyl-Carnitine curve.

Acetyl-Carnitine curve.


Just thought I’d share a fairly interesting discovery with people; not sure if this is well known already, worth checking however.

Before I proceed, could somebody please move this post to the supplements section at their leisure, thank you.

Peyronie’s Disease:

Peyronie’s disease is characterized by a curvature of the penis that leads to pain during an erection because of blocked blood flow. One promising study compared acetyl-L-carnitine to tamoxifen in 48 men with this condition. Acetyl-L-carnitine worked better than the medication at reducing pain during intercourse and minimizing the curve of the penis. Acetyl-L-carnitine also had fewer side effects than tamoxifen. Although the study results are encouraging, more research is needed.

Typical adult dosages for the diseases described here range from 500 mg to 1,000 mg three times daily. For children, one study used 50 mg/kg twice daily, up to a maximum of 4 g daily.73

I’m guessing this may help to correct even slightly less serious curvatures of the penis; only a guess however and sadly: no mechanism of action has been established.


Please add a link to where you got this stuff, or mention author(s) and publication.

Biagiotti G, Cavallini G. Acetyl-L-carnitine vs tamoxifen in the oral therapy of Peyronie’s disease: a preliminary report. BJU Int. 2001;88(1):63-67.



Acetyl-L-carnitine vs tamoxifen in the oral therapy of Peyronie’s disease: a preliminary report.
BJU Int. 2001 Jul;88(1):63-7. Biagiotti G, Cavallini G. Andros-Italia, Perugia, Italy.
To detect whether oral acetyl-L-carnitine might be useful in the acute and early chronic phases of Peyronie’s disease, compared with tamoxifen, a drug currently in use. The study included 48 patients with Peyronie’s disease (15 acute and 33 initial chronic), randomized equally into two groups. The first group used tamoxifen 20 mg twice daily for 3 months and the second acetyl-L-carnitine 1 g twice daily for 3 months. The disease and stages were diagnosed and identified using a history, objective examination, pharmacologically induced erection, autophotography during erection, and basic and dynamic colour Doppler ultrasonography. Penile curvature, plaque size, pain and disease progression were assessed. The differences between the groups or between the variables before and after therapy were compared using analysis of variance or the chi-squared test. Acetyl-L-carnitine was significantly more effective than tamoxifen in reducing pain and in inhibiting disease progression. Acetyl-L-carnitine reduced penile curvature significantly, while tamoxifen did not; both drugs significantly reduced plaque size. Tamoxifen induced significantly more side-effects than acetyl-L-carnitine. These results suggest that acetyl-L-carnitine is significantly more effective and safe than tamoxifen in the therapy of acute and early chronic Peyronie’s disease.



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