Thunder's Place

The big penis and mens' sexual health source, increasing penis size around the world.

Stem Cell Penis Enlargement

12

<<<just to come to terms with your size.>>>

The term I have come too is this: it’s too fucking small. I’m a little over 6’2”, wear between a size 13 and 14 shoe depending upon the maker, and I’ve been able to comfortably and easily palm a basketball since I was fifteen. With all of that allusion towards SIZE, I have more than fifty times noted times when women said they’d “expect” that I had a big dick (which is something they tell me in that way which infers that they really do expect that I’ve got a big unit and that if I answer back that, “yeah, you’re right, I’m hung” that they would deffinitely be willing to investigate that assertion). If my dick was proportional to my body I’d be at least 7.5 EBP. However, I’m 6”. I’ve even noted when bedding chicks that they’re sometimes suprised (and yes, sometimes dissappointed) by my dick which is disproportionate to my other appendages and bone structure- and NOT in a good way. Again, I’ve found that terms have been reached- the dick is too small and so it must therefore DIE so that a BIGGER, STRONGER, FUCKIER cock can rise up and take it’s place.

Haven’t done my first remeasure yet, but *damn* the shit is certainly hanging more like a man’s cock now when it’s flaccid- kind of fat and veiny and deffinitely longer.

I love this shit. Found it right when I had pretty much accepted my situation and now I’m *changing it*

glorious!

My bet is that a rogue scientist with a small penis will buy a facility in Madagascar, start up some experiments and in 6 months, rumors will be reaching us about a giant-dicked wildman in a tattered white lab coat who stalks the local villagers, who in turn offer virgins tied to poles to appease his unnatural sexual appetite.

Adult Stem Cell Therapy For Erectile Dysfunction
Main Category: Erectile Dysfunction / Premature Ejaculation
Also Included In: Stem Cell Research; Urology / Nephrology; Men’s health
Article Date: 26 Jun 2008 - 0:00 PDT

ORLANDO, FL (UroToday.com) - Dr. Tom Lue discussed autologous stem cell use for ED. He discussed that ability for the planarian species to regenerate any part of its body, but the salamander can only regenerate a limb. In man there are also stem cells, which are undifferentiated cells that have potential to also regenerate.

In adipose tissue there are stem cells as demonstrated by immunohistochemistry, RT-PCR and Western blotting experiments. The adipose derived stem cells (ADSCs) reside near small blood vessels. CD34 staining identifies 60% of peri-vascular areas as harboring ADSCs. It occurs in new blood vessels, and is a sign of regeneration. ADSCs can be harvested by liposuction or fat excision. Adipose cells are digested and ADSCs are cultured for further induction, labeling or gene transfection. ADSCs can also be used for in vivo tissue engineering.

In vitro induction can result in hepatocytes, beta cells to produce insulin or endothelial cells. In vivo, ADSCs placed in muscle can differentiate into skeletal muscle, placed near blood vessels become smooth muscle and in fat can become fat cells. The differentiate into component cell types and integrate into the tissue. Four weeks after injection of ADSCs following cavernous nerve crush injury in a rat model, there is return of function. In older men, he proposed using autologous ADSCs to regenerate erectile function. In rats there is suggestion of differentiation. In a type 2 diabetic rat model of ED, use of ADSCs resulted in improved intracavernosal pressures. He showed neurite cell growth in vitro, that is stimulated by the addition of ADSCs. Experiments using ADSCs to stimulate endothelial cell growth also suggested that this is possible.

A study showed injection of umbilical cord blood stem cells into men having failed PDE5 inhibitors resulted in improved erectile function. This is only a pilot experiment, but shows great promise.

Presented by Tom F. Lue, MD, at the Annual Meeting of the American Urological Association (AUA) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA.

Reported by UroToday.com Contributing Editor Christopher P. Evans, MD, FACS

UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice.

To access the latest urology news releases from UroToday, go to: www.urotoday.com

Copyright © 2008 - UroToday


Let me tell you the secret that has led me to my goal: my strength lies solely in my tenacity.

Louis Pasteur

ADULT STEM CELL BREAKTHROUGH FOR PENIS ENLARGEMENT (PHALLOPLASTY) PATIENTS

We are pleased to announce that we have been extracting adult stem cells from our patients’ fat and adding them to the Free Fat Transfer for the last six months and have observed a marked improvement in the amount of take of the Free Fat Transfer, thus improving our results significantly in penile girth enlargement.

We have known for a long time that fat is not just a jelly like padding but a very complex metabolic powerhouse and energy reserve. There are 100x’s more adult stem cells in fat than there are in bone marrow. In fact, for every 30cc (1oz) of fat that we extract and prepare there are an average of 14 million stem cells!! These are readily available for immediate use unlike other sources which take days or weeks of culturing.

In addition fat tissue contains many types of other regenerative cells such as vascular lining cells and smooth muscle cells which aid in healing and repair by promoting blood vessel growth and keeping injured cells alive.

I am now able to extract these stem cells (and others) and use them in all sorts of cosmetic procedures such as: Stem Cell Face Lift for smoother, more natural results; Penile Enlargement; Correction of all sorts of congenital or traumatic depression defects; cosmetic breast enlargements instead of implants; treatment of cellulite, etc.
The future is very bright and exciting.

Sincerely,

Stephen Xavier Giunta, M.D., F.I.C.S

http://www.drgiunta.com/fat-transfer-stemcells.html


Let me tell you the secret that has led me to my goal: my strength lies solely in my tenacity.

Louis Pasteur

Originally Posted by marinera
I wouldn’t trust so much Dr. Stephen Xavier Giunta.

Yea, I had never heard of him. Site looks a little shady but intresting never-the-less.


Let me tell you the secret that has led me to my goal: my strength lies solely in my tenacity.

Louis Pasteur

Originally Posted by marinera

I wouldn’t trust so much Dr. Stephen Xavier Giunta.

I can vouch for Dr. Giunta. His work on me was exceptional.

2013 Update - Stem Cell, Vascular regen. ED & PE

Article: Vascular regenerative therapies for the treatment of erectile dysfunction: current approaches.
From Journal, Andrology, Volume 1, Issue 4, pages 533–540, July 2013

R. A. Condorelli1, A. E. Calogero1, E. Vicari1, V. Favilla2, G. Morgia2, S. Cimino2, S. La Vignera1,*

(excerpt conclusion… use in other applications such as the reconstruction of penile tissue, enlargement of the penis…)

Partial Article…

Section, Adipose tissue stem cell therapy for erectile dysfunction;
Adipose tissue stem cell (ADSCs) isolated from the stromal vascular fraction of adipose tissue have been investigated concerning their multiple differentiation characteristics. They share properties of other stem cells, such as the ability to divide and renew themselves over long periods of time and to differentiate into specialized cells. They are easily obtained in large quantities; therefore, they appear to be a promising option as a clinical application for ED regeneration medicine.
In 2009, an interesting study was conducted in ADSCs to evaluate whether they could differentiate into endothelial cells in the penis, with the aim of identifying the underlying mechanisms of endothelial differentiation of ADSCs (Ning et al., 2009). To evaluate their endothelial differentiation in vivo, ADSCs were marked with bromodeoxyuridine (BrdU), injected into mouse corpora cavernosa and localized by immunofluorescence microscopy in various phases. For endothelial differentiation in vitro, ADSCs were cultured in the appropriate endothelial growth media (EGM2), stained for the endothelial markers CD31, vWF, and eNOS, and then evaluated for the ability to form tubular structures in matrigel and phagocytose acetylated LDL (LDL-Ac). To identify factors that promote endothelial differentiation, ADSCs were cultured in various media, each one containing a specific combination of additional factors in EGM2, and the uptake of LDL was evaluated. PD173074, a selective inhibitor of the fibroblast growth factor 2 (FGF2) receptor, was used to confirm the importance of FGF2 in the signalling pathway for endothelial differentiation for ADSCs. In vivo, 4 weeks after injection at the penile level, ADSCs were positive for BrdU and for the antigen endothelial cell of rats 1 (RECA-1). In contrast, it was observed in vitro that ADSCs that express endothelial markers multiplied more rapidly in the middle EGM2, rather than in the traditional culture medium, DMEM (Dulbecco’s Modified Eagle’s Medium). These properties are reduced in populations of ADSCs grown in the absence of FGF2, and endothelial differentiation is not observed with PD173074 treatment. This finding underscores the importance of the FGF2 growth factor in the repair of penile endothelial damage, and it opens new horizons in the field of ED treatment. Lin and collaborators have shown that ADSCs in culture medium supplemented with FGF2 can differentiate into endothelial cells, which can be injected into the corpora cavernosa of rats with ED, thereby enabling the recovery of poor erectile function (Lin et al., 2009).
In 2010, Garcia and his team once again studied the therapeutic use of ADSCs in subjects with diabetes mellitus type 2, in which ED is a frequent and important complication (Garcia et al., 2010). The study was conducted on 22 diabetic, fat, impotent rats. At 22 weeks of age, all animals were subjected to unilateral stimulation of the cavernous nerve, and the intracavernous pressures (ICP) and blood glucose levels were measured. Subsequently, the adipose perigonadal tissue was collected to obtain the ADSCs, and at 23 weeks of age, one million ADSCs were injected into the penis of the treatment group rodents, whereas the control group received only the vehicle. Erectile function was re-evaluated after 26 weeks, and a sample of tissue was taken for histological analysis. The results showed that after treatment, the stimulation of the cavernous nerve induced a greater increase in ICP compared with the controls, and an increase in the ICP/mean arterial pressure (MAP) ratio was also observed. Moreover, in the removed tissue, greater production of nNOS and a greater number of endothelial cells in the corpora cavernosa was observed. However, given that only a small contingent of ADSCs was found in the corpora cavernosa, it seems that the improvement in erectile function and the microarchitecture of the corpus cavernosum itself can be attributed to the paracrine action of NO rather than ADSC endothelial differentiation.
Hyperlipidaemia is also widely associated with ED; thus, ADSCs may be of therapeutic utility in this condition. A study was conducted on male rats that were induced to develop hyperlipidaemia through a high-fat diet (hyperlipidemic rats, HR), while a group that was fed with a normal diet served as the control (normal rats, NR) (Huang et al., 2010). Five months later, ADSCs were isolated from the perigonadal fat of all rats. The cells were cultured for 1 week, marked with 5-ethynyl-2′-deoxyuridine (EDU) and then injected in the corpora cavernosa of 18 HR, whereas 10 HR were injected phosphate buffer saline (PBS). At two and 14 days post-transplantation, four ADSC-injected HR were sacrificed to monitor the transplanted cells. Twenty-eight days after transplantation, the remaining HR underwent blood testing, evaluation of erectile function, and penile histological examination. Erectile function was estimated by measuring the ICP during electro-stimulation of the cavernous nerve, whereas the cavernous nerves and endothelial and smooth muscle cells were assessed by immunohistochemistry. Total serum cholesterol and LDL were significantly higher in both NR and HR rats, whereas HDL was significantly lower in HR than in NR. The ICP/MAP ratio was reduced in PBS-injected HR or NR, in contrast to ADSC-injected HR. The levels of nNOS-positive nerve fibres and the number of endothelial cells were lower in PBS-injected HR, compared with ADSC-injected HR. Smooth muscle cells were significantly more represented in both HR and NR rats. This suggests that treatment with ADSCs improves the adverse effects of hyperlipidaemia; therefore, this study confirms their potential therapeutic role in ED.
Very recently, another study was carried out on ADSCs to assess their ability to differentiate into smooth muscle and endothelial cells (Orabi et al., 2012). ADSCs were isolated from rats and differentiated into smooth muscle cells and endothelial cells, appropriately labelled, and then used to construct the cavernous tissue. This tissue was subsequently implanted into the penis of normal rats. After 1 and 2 months, the rats were sacrificed, and penile tissue and bone marrow samples were taken to assess cell survival. Using immunohistochemistry, the tissue was stained with haematoxylin-eosin and Masson’s trichrome, The cells had retained the ability for differentiation into smooth muscle cells and endothelial cells, and 2 months later, a significant number survived and were well integrated into penile tissues, supporting the potential for use of ADSCs in the therapeutic treatment of ED.
Another potential use of ADSCs may pertain to the treatment of ED resulting from radiotherapy for prostate cancer (Qiu et al., 2012a). Thirty male rats were divided into the following three groups: a control group that received only an injection of PBS, a group subjected to pelvic irradiation + injection of PBS and the treatment group, which received prostatic irradiation and a subsequent injection of ADSCs marked with EDU. After 17 weeks, erectile function was evaluated by measuring ICP during electrical stimulation of the cavernous nerves, and the penile tissue and major pelvic ganglia were examined by immunofluorescence staining for EDU. The study showed that irradiation significantly alters the mechanisms of erection, most likely as a result of damage to the cavernous nerve. Irradiation also reduced the expression of nNOS and the content of smooth muscle cells at the penile level, however, it did not influence the number of endothelial cells. The injection of ADSCs would regenerate the nerve, allowing for the recovery of erectile function, the expression of nNOS and restoring the content of smooth muscle cells.
ED is often a consequence of prostatectomy, and in such cases, the aetiopathogenetic mechanism is caused by an iatrogenic lesion of the cavernous nerves. Therefore, neuroprotective therapy and the use of stem cells could be promising forms of treatment. In particular, in an experimental model, Piao et al. (2012) evaluated the therapeutic efficacy of ADSCs and brain-derived neurotrophic factor (BDNF). Rats were divided into the following five groups: control group, group with a bilateral lesion of the cavernous nerves, the group receiving ADSCs, the group receiving the BDNF membrane and the group receiving both ADSCs and BDNF. After 4 weeks, the ICP/MAP ratio and the contents of smooth muscle cells and collagen at the penile level were evaluated by Masson’s trichrome staining, whereas the expression of eNOS and cGMP was assessed by immunohistochemistry. In the group of rats treated with ADSCs and BDNF, erectile function and the muscle cells/collagen ratio improved significantly. Furthermore, the quantities of nNOS, eNOS and cGMP significantly increased compared with those in the other four groups. These results suggest new possibilities for the treatment of post-prostatectomy ED.
In conclusion, in our opinion, adipose-derived stem cells are potential candidates for the treatment of ED for many reasons. In fact, these cells can be easily obtained in large quantities and possess the potential to undergo long-term proliferation, self-renewal and multipotent differentiation. In addition, they may find use in other applications such as the reconstruction of penile tissue, enlargement of the penis and in strengthening of the vaginal muscle.

bamuff,

Please post a link when posting excerpts of articles, thanks. Pubmed is fine.


Thunder's Place increasing penis size one dick at a time.

Top
12
Forum Jump

All times are GMT. The time now is 01:39 PM.